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PDX1
Description
pancreatic and duodenal homeobox 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Speck
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Type B Pancreatic Cell Differentiation
Glucose Metabolic Process
Generation Of Precursor Metabolites And Energy
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Glucose
Animal Organ Morphogenesis
Response To Iron(II) Ion
Response To Chlorate
Glucose Mediated Signaling Pathway
Regulation Of Gene Expression
Morphogenesis Of Embryonic Epithelium
Insulin Secretion
Cell Differentiation
Pancreas Development
Exocrine Pancreas Development
Endocrine Pancreas Development
Animal Organ Regeneration
Response To Nutrient Levels
Positive Regulation Of Insulin Secretion
Response To Vitamin
Response To Lipid
Response To Cytokine
Response To Nicotine
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Enteroendocrine Cell Differentiation
Regulation Of Cell Population Proliferation
Glucose Homeostasis
Response To L-leucine
Response To Alkaloid
Type B Pancreatic Cell Proliferation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Response To Glucocorticoid
Transdifferentiation
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Response To Fatty Acid
Type B Pancreatic Cell Apoptotic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Cellular Response To Acadesine
Positive Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways
Regulation of gene expression in beta cells
Regulation of gene expression in early pancreatic precursor cells
Developmental Lineage of Pancreatic Acinar Cells
Developmental Lineage of Pancreatic Ductal Cells
Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases
Permanent neonatal diabetes mellitus (PNDM)
Pancreatic agenesis
Maturity onset diabetes of the young (MODY)
GWAS
Acute insulin response (
28490609
)
Age at first sexual intercourse (
34211149
)
Alanine aminotransferase levels (
33547301
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Birth weight (
31043758
)
Blood sugar levels (
29403010
)
Body mass index (
26426971
)
Fasting blood glucose (
22581228
25631608
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fasting plasma glucose (
28270201
)
Glycated hemoglobin levels (
28898252
)
Pancreatic cancer (
25086665
26098869
29422604
)
Peak insulin response (
28490609
)
Novel Interacting Genes
1 novel interacting genes:
IFT88
Interacting Genes
13 interacting genes:
ATF3
CREB1
IAPP
MAFA
NEUROD1
PBX1
PCIF1
PRKDC
SLC2A2
SPOP
TCF3
XRCC5
XRCC6
Entrez ID
3651
HPRD ID
02843
Ensembl ID
ENSG00000139515
Uniprot IDs
P52945
PDB IDs
6F8F
7KPK
Enriched GO Terms of Interacting Partners
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DNA-dependent Protein Kinase Complex
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nonhomologous End Joining Complex
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulator Complex
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
DNA End Binding
Ku70:Ku80 Complex
Small-subunit Processome Assembly
Positive Regulation Of Macromolecule Biosynthetic Process
Double-stranded DNA Binding
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Protein-DNA Complex
DNA Binding
Chromatin
DNA-binding Transcription Factor Activity
Regulation Of Cell Differentiation
Leukocyte Differentiation
B Cell Lineage Commitment
Response To Gamma Radiation
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Cell Population Proliferation
Positive Regulation Of DNA-templated Transcription
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
5'-deoxyribose-5-phosphate Lyase Activity
Double-strand Break Repair Via Nonhomologous End Joining
Immunoglobulin V(D)J Recombination
Nuclear Telomere Cap Complex
Double-stranded Telomeric DNA Binding
Positive Regulation Of RNA Metabolic Process
DNA Recombination
U3 SnoRNA Binding
Positive Regulation Of Cell Differentiation
Positive Regulation Of Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Hormone Secretion
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Telomere Maintenance
Hormone Transport
Regulation Of Gene Expression
V(D)J Recombination
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Tagcloud
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