PDX1 and TCF3

Number of citations of the paper that reports this interaction (PubMedID 10636926)
0

Data Source:
HPRD (in vivo)

		PDX1	TCF3
Description		pancreatic and duodenal homeobox 1	transcription factor 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Vitamin D Response Element Binding E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Glucose Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Glucose Mediated Signaling Pathway Regulation Of Gene Expression Morphogenesis Of Embryonic Epithelium Insulin Secretion Cell Differentiation Pancreas Development Exocrine Pancreas Development Endocrine Pancreas Development Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Vitamin Response To Lipid Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Enteroendocrine Cell Differentiation Regulation Of Cell Population Proliferation Glucose Homeostasis Response To L-leucine Response To Alkaloid Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Transdifferentiation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To Fatty Acid Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Acadesine Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation B Cell Differentiation Positive Regulation Of B Cell Proliferation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM) Pancreatic agenesis Maturity onset diabetes of the young (MODY)	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Acute insulin response ( 28490609) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 25086665 26098869 29422604) Peak insulin response ( 28490609)	Hodgkin's lymphoma ( 24920014 29196614) Monocyte count ( 32888494) Objective response to lithium treatment ( 26503763) Triglyceride levels ( 34074324)
Interacting Genes		13 interacting genes: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6	66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1
Entrez ID		3651	6929
HPRD ID		02843	00918
Ensembl ID		ENSG00000139515	ENSG00000071564
Uniprot IDs		P52945	P15923
PDB IDs		6F8F 7KPK	2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?		DNA-dependent Protein Kinase Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein-DNA Complex DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Cell Differentiation Leukocyte Differentiation B Cell Lineage Commitment Response To Gamma Radiation Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding 5'-deoxyribose-5-phosphate Lyase Activity Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Positive Regulation Of RNA Metabolic Process DNA Recombination U3 SnoRNA Binding Positive Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hormone Secretion Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Telomere Maintenance Hormone Transport Regulation Of Gene Expression V(D)J Recombination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Cell Differentiation Animal Organ Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Developmental Process Animal Organ Morphogenesis Regulation Of Developmental Process Embryonic Morphogenesis
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