RANBP2 and SENP1

Number of citations of the paper that reports this interaction (PubMedID 22194619)
40

Data Source:
BioGRID (enzymatic study)

		RANBP2	SENP1
Description		RAN binding protein 2	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket SUMO Ligase Complex Cytoplasmic Periphery Of The Nuclear Pore Complex	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity GTPase Activator Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Activator Activity SUMO Transferase Activity Small GTPase Binding Protein-containing Complex Binding Metal Ion Binding SUMO Ligase Activity	Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Response To Amphetamine Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Gluconeogenesis Protein Folding NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Protein Sumoylation Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Centrosome Localization	Proteolysis Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Primary Metabolic Process Regulation Of Postsynapse Assembly
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants	SUMO is proteolytically processed RHOF GTPase cycle
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 29325848) Beard thickness ( 26926045) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		40 interacting genes: AKAP13 ARID4B CALM1 CDCA8 CEBPA CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MAP2K7 MDM2 MYBPC2 NR5A2 NUP62 NXF1 OPN1LW OPN1MW PDLIM3 PRKN PTEN RAN RANGAP1 RNF10 SENP1 SP100 SUMO1 SUMO2 TAF1 TNPO1 TOP2B UBE2I UBTD1 WAS XPO1 XPOT	26 interacting genes: APP CAV3 EIF5A GCM1 HDAC1 HIPK1 HIPK2 KCNK1 MORC2 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28 USP7
Entrez ID		5903	29843
HPRD ID		03111	07153
Ensembl ID		ENSG00000153201	ENSG00000079387
Uniprot IDs		P49792	Q9P0U3
PDB IDs		1RRP 1XKE 1Z5S 2LAS 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW 5CLL 5CLQ 7MNJ 7MNK 7MNL 7MNM 7MNN 7MNO 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7R5J 7R5K 9B62	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?		Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Nucleoplasm Protein Localization To Nucleus Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Transport Nuclear Import Signal Receptor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Organelle Nuclear Localization Sequence Binding Regulation Of Intracellular Protein Transport Establishment Of Localization In Cell Presynaptic Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Transport Positive Regulation Of RNA Biosynthetic Process Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Nucleus Import Into Nucleus Small GTPase Binding Nuclear Export Regulation Of Proteasomal Protein Catabolic Process Cellular Localization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription SUMO Transferase Activity Nuclear Membrane Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process NLS-bearing Protein Import Into Nucleus Regulation Of RNA Biosynthetic Process Intracellular Protein Transport Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Postsynaptic Cytosol Nuclear Envelope Regulation Of Protein Transport Establishment Of Protein Localization To Organelle Cytosol Cytoplasm RNA Transport RNA Export From Nucleus NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process	Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Protein Modification Process Post-translational Protein Modification Protein Metabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Protein Tag Activity Protein-containing Complex Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intracellular Transport Cellular Response To Stress Cytoplasmic Periphery Of The Nuclear Pore Complex DNA Damage Response Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nuclear Body Organization Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization Deubiquitinase Activity Maintenance Of Protein Location In Nucleus Ubiquitin-like Protein Ligase Binding Nuclear Pore Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Postsynaptic Cytosol Negative Regulation Of Transcription By RNA Polymerase II SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments
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