RANBP2 and TAF1

Number of citations: 36 (PubMedID 20936779)
Data Source: BioGRID (two hybrid)

		RANBP2	TAF1
Name		RAN binding protein 2	TATA-box binding protein associated factor 1
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket SUMO Ligase Complex Cytoplasmic Periphery Of The Nuclear Pore Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity GTPase Activator Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Activator Activity SUMO Transferase Activity Small GTPase Binding Protein-containing Complex Binding Metal Ion Binding SUMO Ligase Activity	Nucleotide Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding DNA Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Transferase Activity Acyltransferase Activity Nuclear Receptor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Histone H3K27me3 Reader Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Protein-lysine-acetyltransferase Activity Protein Serine Kinase Activity Histone H4K16ac Reader Activity Transcription Regulator Inhibitor Activity Histone Reader Activity Acetyl-CoA Binding
	Biological Process	Response To Amphetamine Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Gluconeogenesis Protein Folding NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Protein Sumoylation Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Centrosome Localization	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Chromatin Organization Chromatin Remodeling DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Negative Regulation Of Gene Expression Midbrain Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To ATP Positive Regulation Of Androgen Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
GWAS		Attention deficit hyperactivity disorder ( 29325848 ) Beard thickness ( 26926045 ) Monobrow thickness ( 26926045 ) Scalp hair shape ( 26926045 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GCC2	7 novel interactors: FOXO4 KIF4A MED12 NDUFS6 NONO PDZD11 ZMYM3
Interacting Genes		40 interacting genes: AKAP13 ARID4B CALM1 CDCA8 CEBPA CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MAP2K7 MDM2 MYBPC2 NR5A2 NUP62 NXF1 OPN1LW OPN1MW PDLIM3 PRKN PTEN RAN RANGAP1 RNF10 SENP1 SP100 SUMO1 SUMO2 TAF1 TNPO1 TOP2B UBE2I UBTD1 WAS XPO1 XPOT	65 interacting genes: APC APP AR ASF1A ASF1B BRMS1 BRWD1 BTG3 CCNA2 CCND1 CDC42BPA CFAP298 CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS GATD3 GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 HUNK ITGB5 JUN LCOR LHX3 MAX MDM2 MSX1 MYOM2 PAX3 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 TTC3 UBE2I UBTF
Entrez ID		5903	6872
HPRD ID		03111	02436
Ensembl ID		ENSG00000153201	ENSG00000147133
Uniprot IDs		P49792	A0A804HIC2 P21675
PDB IDs		1RRP 1XKE 1Z5S 2LAS 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW 5CLL 5CLQ 7MNJ 7MNK 7MNL 7MNM 7MNN 7MNO 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7R5J 7R5K 9B62	1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGH 7EGI 7EGJ 7ENA 7ENC 7JJG 7JJH 7JSP 7JTC 7K03 7K0D 7K0U 7K1P 7K27 7K3O 7K42 7K6F 7L6X 7LB0 7LB1 7LB2 7LB3 7N42 7P4S 7T2I 7T36 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
GO Terms Enriched among Interactors		Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Nucleoplasm Protein Localization To Nucleus Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Transport Nuclear Import Signal Receptor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Organelle Nuclear Localization Sequence Binding Regulation Of Intracellular Protein Transport Establishment Of Localization In Cell Presynaptic Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Transport Positive Regulation Of RNA Biosynthetic Process Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Nucleus Import Into Nucleus Small GTPase Binding Nuclear Export Regulation Of Proteasomal Protein Catabolic Process Cellular Localization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription SUMO Transferase Activity Nuclear Membrane Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process NLS-bearing Protein Import Into Nucleus Regulation Of RNA Biosynthetic Process Intracellular Protein Transport Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Postsynaptic Cytosol Nuclear Envelope Regulation Of Protein Transport Establishment Of Protein Localization To Organelle Cytosol Cytoplasm RNA Transport RNA Export From Nucleus NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process	Transcription Factor TFIID Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm Transcription Preinitiation Complex Assembly DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly MRNA Transcription Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Factor TFTC Complex DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein-containing Complex Assembly Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Promoter-specific Chromatin Binding Protein Heterodimerization Activity Regulation Of Metabolic Process Nucleic Acid Metabolic Process Cellular Component Assembly