KIF2C and CENPH

Number of citations of the paper that reports this interaction (PMID 11092768)
25

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KIF2C	CENPH
Gene Name		kinesin family member 2C	centromere protein H
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleus Cytosol Kinesin Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Microtubule Plus-end Binding	Protein Binding Kinetochore Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Microtubule Depolymerization Mitotic Nuclear Division Mitotic Metaphase Plate Congression Blood Coagulation Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Regulation Of Chromosome Segregation	Mitotic Cell Cycle Nucleosome Assembly CENP-A Containing Nucleosome Assembly Kinetochore Assembly Kinetochore Organization
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP AURKA CENPH CSNK2B HIST3H3 MAPRE1 VHL ZNF566	5 interactors: CENPK KIF2C MTAP NDC80 NUF2
Entrez ID		11004	64946
HPRD ID		05172	12029
Ensembl ID		ENSG00000142945	ENSG00000153044
Uniprot IDs		B7Z6Q6 Q99661	B3KVZ3 Q9H3R5
PDB IDs		2HEH
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Regulation Of Protein Binding Protein Localization To Cytoskeleton Mitotic Cell Cycle Negative Regulation Of Microtubule Polymerization Or Depolymerization Cell Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Developmental Cell Growth Negative Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Cell Cycle Spindle Assembly Involved In Female Meiosis I Synaptic Growth At Neuromuscular Junction Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Stability Developmental Growth Involved In Morphogenesis Neuron Projection Morphogenesis Spindle Assembly Involved In Meiosis Collateral Sprouting In Absence Of Injury Positive Regulation Of Microtubule Plus-end Binding Regulation Of Microtubule Cytoskeleton Organization Cell Growth Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Spindle Stabilization Regulation Of Microtubule-based Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Projection Development Cellular Component Assembly Cell Projection Morphogenesis Axon Choice Point Recognition Cell Part Morphogenesis Positive Regulation Of Cell Cycle Process Positive Regulation Of Oocyte Maturation Positive Regulation Of Activin Receptor Signaling Pathway Protein Localization To Microtubule Adiponectin-activated Signaling Pathway Meiotic Spindle Organization Protein Localization To Centrosome Neuron Remodeling Mitotic Centrosome Separation Neuron Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Female Meiosis I Developmental Growth Positive Regulation Of Oocyte Development	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Cycle Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Mitotic Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Chromosome Organization Cell Cycle Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Purine Ribonucleoside Salvage Organelle Organization L-methionine Biosynthetic Process From Methylthioadenosine Establishment Of Organelle Localization Microtubule Depolymerization L-methionine Salvage Attachment Of Spindle Microtubules To Kinetochore Organelle Localization Microtubule Cytoskeleton Organization Methionine Biosynthetic Process Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Purine-containing Compound Salvage CENP-A Containing Nucleosome Assembly Mitotic Metaphase Plate Congression Polyamine Metabolic Process Metaphase Plate Congression Histone Exchange DNA Replication-independent Nucleosome Assembly Response To Testosterone Establishment Of Mitotic Spindle Orientation Microtubule Polymerization Or Depolymerization Mitotic Spindle Organization Sulfur Amino Acid Metabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Establishment Of Chromosome Localization Microtubule-based Process Centromere Complex Assembly Spindle Localization Microtubule Anchoring ATP-dependent Chromatin Remodeling Regulation Of Chromosome Segregation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Tagcloud ?		acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis	angptl2 bik blast blasts candidate causative commercial cytopenia dysplasia epigenetic excess focusing gstm5 hypermethylation mapped methylated methylation modalities multilineage networks pairs preleukemic promoters raeb rcmd refractory rerg silencing transforms
Tagcloud (Difference) ?		acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter targets tumorigenesis	angptl2 bik blast blasts candidate causative commercial cytopenia dysplasia epigenetic excess focusing gstm5 hypermethylation mapped methylated methylation modalities multilineage networks pairs preleukemic promoters raeb rcmd refractory rerg transforms
Tagcloud (Intersection) ?		silencing