KIF2C and ZNF566

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		KIF2C	ZNF566
Description		kinesin family member 2C	zinc finger protein 566
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end Presynapse Postsynapse Glutamatergic Synapse	Nucleus
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Centromeric DNA Binding Microtubule Plus-end Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule-based Movement Microtubule Depolymerization Chromosome Segregation Mitotic Metaphase Chromosome Alignment Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Cytoskeleton Organization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	Generic Transcription Pathway
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS
Interacting Genes		11 interacting genes: APP AURKA CEBPA CENPH CSNK2B H3-4 NDEL1 PLK1 SUMO2 VHL ZNF566	6 interacting genes: EXOC8 KIF2C KIF9 MAGOHB TRIM55 TRIM63
Entrez ID		11004	84924
HPRD ID		05172	15847
Ensembl ID		ENSG00000142945	ENSG00000186017
Uniprot IDs		A0A140VKF1 B7Z6Q6 B7Z7M6 Q99661	B4DRR6 Q969W8
PDB IDs		2HEH 4UBF 4Y05 5MIO
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Centrosome Separation Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Kinetochore Mitotic Centrosome Separation Axon Hillock Mitotic Spindle Organization Positive Regulation Of Catabolic Process Regulation Of Neurotransmitter Uptake Developmental Cell Growth Protein Heterodimerization Activity Protein Serine/threonine Kinase Binding Molecular Function Activator Activity Developmental Growth Involved In Morphogenesis Chromosome Segregation Protein Localization To Centrosome Spindle Midzone Amyloid Fibril Formation Spindle Organization Chromosome, Centromeric Region Centrosome Localization Microtubule-based Process Establishment Of Mitotic Spindle Orientation Positive Regulation Of Protein Metabolic Process Mitotic Spindle Pole Microtubule Cytoskeleton Organization Establishment Of Mitotic Spindle Localization Spindle Microtubule Peptidyl-serine Phosphorylation Establishment Of Spindle Orientation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Cytoskeleton Centrosome Cycle Histone H3K36me2/H3K36me3 Demethylase Activity	Microtubule Kinesin Complex Extracellular Matrix Disassembly Microtubule Motor Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Exon-exon Junction Subcomplex Mago-y14
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