VCPIP1 and WAC

Number of citations of the paper that reports this interaction (PubMedID 23500464)
0

Data Source:
BioGRID (pull down)

		VCPIP1	WAC
Description		valosin containing protein interacting protein 1	WW domain containing adaptor with coiled-coil
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Stack	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	DNA Repair Proteolysis DNA Damage Response Golgi Organization Endoplasmic Reticulum Membrane Fusion Protein Ubiquitination Protein Deubiquitination Protein K11-linked Deubiquitination Protein K48-linked Deubiquitination Golgi Reassembly Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin	Chromatin Organization Chromatin Remodeling DNA Damage Response Regulation Of Autophagy Positive Regulation Of Macroautophagy Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of TORC1 Signaling
Pathways		Ovarian tumor domain proteases	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma ( 27363682)
Interacting Genes		11 interacting genes: FCHSD2 GSK3A HUNK SMAD9 SNTG2 SPRTN STX5 UBC VAV2 VCP WAC	29 interacting genes: AKAP9 APP BACH1 CCDC6 CDC37 CDK1 CRKL DYDC1 HMG20B KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 PLK1 SYTL5 TFIP11 TNS2 TRAF1 TRAF3IP1 TRAF3IP3 TTC3 UBC UBQLN4 VCP VCPIP1 ZDHHC17
Entrez ID		80124	51322
HPRD ID		15645	18291
Ensembl ID		ENSG00000175073	ENSG00000095787
Uniprot IDs		Q96JH7	Q9BTA9
PDB IDs		8YKA
Enriched GO Terms of Interacting Partners?		Protein-DNA Covalent Cross-linking Repair Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Translesion Synthesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Postreplication Repair Polyubiquitin Modification-dependent Protein Binding DNA Synthesis Involved In DNA Repair Interstrand Cross-link Repair Regulation Of Post-translational Protein Modification Negative Regulation Of UDP-glucose Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Stereocilium Shaft Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Organelle Disassembly VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination DNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Cytoplasm Protein Quality Control BAT3 Complex Binding Syntrophin Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signal Transduction Positive Regulation Of Protein Deubiquitination Neuroligin Family Protein Binding Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Viral Process	Cytoplasm Post-translational Protein Modification Protein Modification By Small Protein Conjugation Response To Copper Ion Microtubule-based Process Identical Protein Binding Protein Modification Process Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Protein Ubiquitination Microtubule Binding Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Mitotic Nuclear Membrane Disassembly DNA Metabolic Process DNA Repair Centrosome Separation Transport Along Microtubule Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nuclear Membrane Disassembly Cytoskeleton-dependent Intracellular Transport Membrane Disassembly Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Microtubule-based Transport Cellular Response To Copper Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Microtubule Cytoskeleton Organization Protein Localization To Site Of Double-strand Break Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Cytoskeleton Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium
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