VCPIP1 and SPRTN

Number of citations of the paper that reports this interaction (PubMedID 32649882)
37

Data Source:
BioGRID (affinity chromatography technology, imaging technique, enzymatic study)

		VCPIP1	SPRTN
Description		valosin containing protein interacting protein 1	SprT-like N-terminal domain
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Stack	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck
	Molecular Function	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	DNA Repair Proteolysis DNA Damage Response Golgi Organization Endoplasmic Reticulum Membrane Fusion Protein Ubiquitination Protein Deubiquitination Protein K11-linked Deubiquitination Protein K48-linked Deubiquitination Golgi Reassembly Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin	DNA Repair Proteolysis DNA Damage Response Response To UV Protein Autoprocessing Translesion Synthesis Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair Protein-DNA Covalent Cross-linking Repair
Pathways		Ovarian tumor domain proteases	Translesion Synthesis by POLH
Drugs
Diseases
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		11 interacting genes: FCHSD2 GSK3A HUNK SMAD9 SNTG2 SPRTN STX5 UBC VAV2 VCP WAC	5 interacting genes: KPNA4 RNF11 UBC VCP VCPIP1
Entrez ID		80124	83932
HPRD ID		15645	13164
Ensembl ID		ENSG00000175073	ENSG00000010072
Uniprot IDs		Q96JH7	Q9H040
PDB IDs		8YKA	5IY4 6MDW 6MDX
Enriched GO Terms of Interacting Partners?		Protein-DNA Covalent Cross-linking Repair Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Translesion Synthesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Postreplication Repair Polyubiquitin Modification-dependent Protein Binding DNA Synthesis Involved In DNA Repair Interstrand Cross-link Repair Regulation Of Post-translational Protein Modification Negative Regulation Of UDP-glucose Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Stereocilium Shaft Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Organelle Disassembly VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination DNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Cytoplasm Protein Quality Control BAT3 Complex Binding Syntrophin Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signal Transduction Positive Regulation Of Protein Deubiquitination Neuroligin Family Protein Binding Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Viral Process	Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Hippo Signaling Proteolysis Protein Modification Process Modification-dependent Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Proteolysis Involved In Protein Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Cytoplasm Protein Quality Control BAT3 Complex Binding Positive Regulation Of Protein Deubiquitination Golgi Reassembly Endoplasmic Reticulum Membrane Fusion Dopamine Secretion Macromolecule Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Macromolecule Catabolic Process Stress Granule Disassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Deubiquitinase Activator Activity Catecholamine Secretion Derlin-1 Retrotranslocation Complex Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex NLS-dependent Protein Nuclear Import Complex Ubiquitin Protein Ligase Binding Regulation Of Protein Deubiquitination Positive Regulation Of Membrane Potential K48-linked Polyubiquitin Modification-dependent Protein Binding ATPase Complex Ubiquitin-modified Protein Reader Activity Cellular Response To Misfolded Protein Protein K11-linked Deubiquitination Protein Metabolic Process Positive Regulation Of Cellular Respiration Response To Misfolded Protein Positive Regulation Of ATP Biosynthetic Process Protein Tag Activity Endoplasmic Reticulum Membrane Organization
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