PPM1B and CDK6

Number of citations of the paper that reports this interaction (PMID 10934208)
25

Data Source:
HPRD (in vitro)

		PPM1B	CDK6
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1B	cyclin-dependent kinase 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding
	Biological Process	Protein Dephosphorylation N-terminal Protein Myristoylation Cytokine-mediated Signaling Pathway Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 23563607)	Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		9 interactors: CDK2 CDK6 ECHS1 IKBKB IKBKG MAP3K7 MSN PPARG VAV2	92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1
Entrez ID		5495	1021
HPRD ID		04796	04533
Ensembl ID		ENSG00000138032	ENSG00000105810
Uniprot IDs		O75688	A4D1G0 Q00534
PDB IDs		2P8E	1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Fc-epsilon Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Fc Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity I-kappaB Phosphorylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Regulation Of Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Immune Response Positive Regulation Of Immune Response Defense Response Positive Regulation Of NIK/NF-kappaB Signaling B Cell Homeostasis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling	RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		2c aging arrest attenuating cellular depletion evidenced importantly imr inactivating induces involvement mapk member negatively organismal p38 partially phosphatase possibly program progressively regulating regulator replicative rescued robust senescence thereby	a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		2c aging arrest attenuating cellular depletion evidenced importantly imr inactivating induces involvement mapk member negatively organismal p38 partially phosphatase possibly program progressively regulating regulator replicative rescued robust senescence thereby	a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?