PPM1B and MAP3K7

Number of citations of the paper that reports this interaction (PubMedID 11104763)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		PPM1B	MAP3K7
Description		protein phosphatase, Mg2+/Mn2+ dependent 1B	mitogen-activated protein kinase kinase kinase 7
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane ATAC Complex
	Molecular Function	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Cation Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Kinase Activity Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Kinase Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Linear Polyubiquitin Binding
	Biological Process	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Remodeling Apoptotic Process Inflammatory Response Immune Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interleukin-2 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway Defense Response To Bacterium Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Cell Size T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Angiotensin
Pathways		ISG15 antiviral mechanism ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 29273806 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Cortical surface area ( 32963231) Cortical volume ( 32963231) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		21 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAD2L2 MAP3K7 MSN MYL7 PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2	73 interacting genes: AKTIP BBS10 BCL10 CALML6 CAMK2G CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IL17RD IRAK1 MAILR MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB SUPT20H TAB1 TAB2 TGFBR1 TNFAIP8L2 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC USP29 USP4 USP8 VRK2 XIAP ZNF593 ZNF746
Entrez ID		5495	6885
HPRD ID		04796	04011
Ensembl ID		ENSG00000138032	ENSG00000135341
Uniprot IDs		O75688	O43318
PDB IDs		2P8E	2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N 7NTH 7NTI 8GW3 9FPD
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity ATP Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Coreceptor Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion ERBB2 Signaling Pathway Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Linear Polyubiquitin Binding Regulation Of Epithelial Cell Proliferation Wnt-protein Binding Phosphorylation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Histone Kinase Activity Regulation Of Cell Motility Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction IkappaB Kinase Complex Positive Regulation Of Phosphate Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction	Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Signal Transduction Innate Immune Response-activating Signaling Pathway Protein Kinase Activity Regulation Of Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Non-canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Protein Modification Process Regulation Of Defense Response Negative Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Innate Immune Response Response To Stress Regulation Of MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasm Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Immune Response Regulation Of DNA-binding Transcription Factor Activity Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Immune Response-regulating Signaling Pathway Cytosol Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Regulation Of Immune System Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Transferase Activity
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