PRKCQ and GRM5

Number of citations of the paper that reports this interaction (PMID 15894802)
16

Data Source:
HPRD (in vitro)

		PRKCQ	GRM5
Gene Name		protein kinase C, theta	glutamate receptor, metabotropic 5
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Astrocyte Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Metal Ion Binding	G-protein Coupled Receptor Activity Glutamate Receptor Activity A2A Adenosine Receptor Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Inflammatory Response Axon Guidance Blood Coagulation Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Protein Ubiquitination Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation	Activation Of MAPKKK Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Locomotory Behavior Negative Regulation Of Locomotion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Synaptic Transmission, Glutamatergic
Pathways		G alpha (q) signalling events Signaling by GPCR Downstream TCR signaling Axon guidance Effects of PIP2 hydrolysis FCERI mediated NF-kB activation Inactivation, recovery and regulation of the phototransduction cascade Gastrin-CREB signalling pathway via PKC and MAPK The phototransduction cascade Programmed Cell Death G alpha (z) signalling events Netrin-1 signaling Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase Diseases associated with visual transduction G alpha (q) signalling events GPCR downstream signaling TCR signaling Visual phototransduction Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Staurosporine Phosphonothreonine Phosphonoserine	Acamprosate Rufinamide
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266) Body mass index (asthmatics) ( 23517042) Immune response to smallpox vaccine (IL-6) ( 22542470) Rheumatoid arthritis ( 18794853 20453842) Type 1 diabetes ( 19430480 18978792)	Attention deficit hyperactivity disorder ( 22012869) Tanning ( 19340012)
Protein-Protein Interactions		28 interactors: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN NFE2L2 RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ	19 interactors: CALM1 CALM2 CALM3 DYT10 EFNB2 FLNA GPRASP1 GRASP HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1
Entrez ID		5588	2915
HPRD ID		02710	04980
Ensembl ID		ENSG00000065675	ENSG00000168959
Uniprot IDs		Q04759	A8K5P7 P41594
PDB IDs		1XJD 2ENJ 2ENN 2ENZ 2JED	3LMK
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Immune System Process T Cell Costimulation Regulation Of Cell Death Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor T Cell Receptor Signaling Pathway Signal Transduction Regulation Of Signaling Immune Response Regulation Of Lymphocyte Activation Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Defense Response Lymphocyte Homeostasis Signaling Response To Growth Factor Cell Communication Response To Organic Substance Response To Stress Cellular Response To Stimulus Regulation Of T Cell Activation Leukocyte Homeostasis Phosphorylation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus	Platelet Activation Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Blood Coagulation Hemostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Phototransduction, Visible Light Signal Transduction Synaptic Transmission Cellular Response To Growth Factor Stimulus Activation Of Adenylate Cyclase Activity Cell-cell Signaling Response To Growth Factor Detection Of Visible Light Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Phototransduction Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Transport Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intracellular Signal Transduction Cell Communication
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 rpa3 softwares vav3 zap70	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 rpa3 softwares vav3 zap70	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?