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PRKCQ and SELL
Number of citations of the paper that reports this interaction (PubMedID
15192100
)
0
Data Source:
BioGRID
(pull down)
PRKCQ
SELL
Description
protein kinase C theta
selectin L
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aggresome
Centriolar Satellite
Extracellular Space
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Secretory Granule Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protease Binding
Calcium Ion Binding
Protein Binding
Heparin Binding
Carbohydrate Binding
Sialic Acid Binding
Glycosphingolipid Binding
Metal Ion Binding
Oligosaccharide Binding
Biological Process
Regulation Of Cell Growth
Immune System Process
Regulation Of DNA-templated Transcription
Membrane Protein Ectodomain Proteolysis
Inflammatory Response
Axon Guidance
Positive Regulation Of Telomere Maintenance
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Intracellular Signal Transduction
CD4-positive, Alpha-beta T Cell Proliferation
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Chemotaxis
Negative Regulation Of T Cell Apoptotic Process
Regulation Of Platelet Aggregation
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of T-helper 2 Cell Activation
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Response To Cytokine
Leukocyte Migration
Leukocyte Tethering Or Rolling
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways
Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Downstream TCR signaling
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
Netrin-1 signaling
G alpha (z) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RAS processing
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Neutrophil degranulation
Drugs
Tamoxifen
Staurosporine
Staurosporine
Phosphonothreonine
Dequalinium
Dexfosfoserine
Benzoyl peroxide
Fostamatinib
Diseases
Type I diabetes mellitus
GWAS
Asthma (
31959851
30929738
)
Asthma (bronchodilator response) (
23508266
)
Asthma (childhood onset) (
31036433
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index in asthmatics (
23517042
)
Celiac disease (
22057235
24999842
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Chronic pain (
33685280
)
Crohn's disease (
28067908
)
Factor VII activity (
30642921
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Medication use (thyroid preparations) (
31015401
)
Rheumatoid arthritis (
30423114
24390342
18794853
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Type 1 diabetes (
19430480
18978792
)
Acne (severe) (
24399259
)
Amyotrophic lateral sclerosis (
19451621
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
L-selectin levels (
25576479
)
Monocyte count (
32888494
)
Interacting Genes
27 interacting genes:
AKT1
BTK
CARD11
CASP3
CBL
CHUK
CISH
FYN
GLRX3
GRM5
HABP4
ICAM3
IKBKB
IKBKG
IRS1
LCK
LYN
MARK3
MSN
RASGRP3
SELL
STK39
TAL1
VAV1
WIPF1
YWHAG
YWHAQ
16 interacting genes:
CD4
CFH
EMCN
EZR
GRB2
MSN
MUC7
PODXL
PODXL2
PRKCA
PRKCQ
PRKG1
SELE
SELPLG
SLC30A2
VCAN
Entrez ID
5588
6402
HPRD ID
02710
07034
Ensembl ID
ENSG00000065675
ENSG00000188404
Uniprot IDs
Q04759
P14151
PDB IDs
1XJD
2ENJ
2ENN
2ENZ
2JED
4Q9Z
4RA5
5F9E
2LGF
3CFW
5VC1
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
T Cell Costimulation
Immune Response-activating Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Fc Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Immune System Process
Positive Regulation Of Lymphocyte Activation
Immune System Process
Antigen Receptor-mediated Signaling Pathway
Regulation Of Lymphocyte Activation
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Leukocyte Cell-cell Adhesion
T Cell Receptor Signaling Pathway
Signal Transduction
Regulation Of Cell Activation
Membrane Raft
Intracellular Signaling Cassette
Positive Regulation Of Cell-cell Adhesion
Protein Phosphorylation
Regulation Of Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Protein Kinase Activity
Regulation Of Cell-cell Adhesion
Leukocyte Migration
Leukocyte Proliferation
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Phosphorylation
IkappaB Kinase Complex
Leukocyte Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Fc-gamma Receptor Signaling Pathway
Homeostatic Process
Response To Xenobiotic Stimulus
Cytosol
Leukocyte Cell-cell Adhesion
Cell Adhesion
Regulation Of Cell-cell Adhesion
Uropod
Plasma Membrane
Leukocyte Tethering Or Rolling
Leukocyte Adhesion To Vascular Endothelial Cell
Microvillus Membrane
Regulation Of Platelet Aggregation
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Cell Migration
Membrane To Membrane Docking
Positive Regulation Of Cell-cell Adhesion
Regulation Of Platelet Activation
Cell Motility
Regulation Of Interleukin-2 Production
Positive Regulation Of Early Endosome To Late Endosome Transport
Microvillus
Regulation Of Immune System Process
Positive Regulation Of Protein Localization To Early Endosome
Filopodium
Positive Regulation Of Protein Localization To Endosome
Cell-cell Adhesion
Positive Regulation Of Leukocyte Cell-cell Adhesion
Immune System Process
Golgi Lumen
Establishment Of Epithelial Cell Apical/basal Polarity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Leukocyte Activation
Regulation Of Early Endosome To Late Endosome Transport
T Cell Activation
Establishment Of Apical/basal Cell Polarity
Positive Regulation Of Immune System Process
Regulation Of Cell Activation
Glycosaminoglycan Binding
Epithelial Cell Development
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Polarized Epithelial Cell Differentiation
Cell Activation
Cortical Cytoskeleton
Gland Morphogenesis
Establishment Of Epithelial Cell Polarity
Regulation Of Leukocyte Cell-cell Adhesion
Signaling Receptor Binding
Actin Filament-based Process
Plasma Membrane Raft
Positive Regulation Of Interleukin-2 Production
Establishment Of Endothelial Barrier
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