UCHL1 and PARK2

Number of citations of the paper that reports this interaction (PMID 25403879)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		UCHL1	PARK2
Gene Name		ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	parkin RBR E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm LUBAC Complex Lewy Body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding	G-protein Coupled Receptor Binding Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity SH3 Domain Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Protein Deubiquitination Sensory Perception Of Pain Axon Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process	Protein Polyubiquitination Mitochondrial Fission Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Startle Response Transcription, DNA-templated Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Regulation Of Autophagy Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Regulation Of Dopamine Secretion Protein Ubiquitination Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Norepinephrine Metabolic Process Dopamine Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Protein K27-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Zinc Ion Homeostasis Negative Regulation Of Cell Death Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Cognitive performance ( 19734545)	Aging ( 22773346) Disc degeneration (lumbar) ( 22993228) Metabolite levels ( 19043545) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		27 interactors: ADRA2A ADRA2B ADRA2C ADRB2 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PARK2 PLA2G2A RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	77 interactors: AIMP2 ARR3 ARRB2 ATXN3 BAG5 CASK CASP1 CASP8 CDK5 CHPF CRX CSNK1A1 CUL1 DLG1 DLX2 DNM1L DYT10 EPS15 FAM46C FBP1 FBXO7 FBXW7 GPR37 GRIN2B HEXDC IKBKG MEOX1 MEOX2 MFN1 NDUFA4L2 PAFAH1B2 PDCD2 PICK1 PRKACA PSMA1 PSMA7 PSMC5 PSMD4 RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 SEPT4 SEPT5 SIM2 SNCA SNCAIP STUB1 SYT11 TCF4 TOMM40 TOMM70A TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2J1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2V1 UCHL1 YWHAH ZNF746
Entrez ID		7345	5071
HPRD ID		01877	03967
Ensembl ID		ENSG00000154277	ENSG00000185345
Uniprot IDs		P09936	O60260 Q5VVX4
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9	1IYF 2JMO 4BM9 4I1F 4I1H
Enriched GO Terms of Interacting Partners?		Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Receptor Transactivation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Norepinephrine Secretion Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Catabolic Process Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Activation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorylation Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Phosphorylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Response To Abiotic Stimulus Negative Regulation Of Muscle Contraction Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ERBB Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Response To Stimulus Positive Regulation Of Protein Metabolic Process	Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Death Death Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud ?		1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?