NCAM1 and SPTB

Number of citations of the paper that reports this interaction (PMID 12743109)
33

Data Source:
HPRD (in vitro)

		NCAM1	SPTB
Gene Name		neural cell adhesion molecule 1	spectrin, beta, erythrocytic
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Spectrin Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein Complex
	Molecular Function	Identical Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Cell Adhesion Axon Guidance Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Interferon-gamma-mediated Signaling Pathway	Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Axon Guidance Hemopoiesis Actin Filament Capping
Pathways		Interferon gamma signaling Signal transduction by L1 NCAM1 interactions Axon guidance ECM proteoglycans Interferon Signaling L1CAM interactions Cytokine Signaling in Immune system NCAM signaling for neurite out-growth	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Entorhinal cortical thickness ( 21116278) Left ventricular mass ( 21212386)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	11 interactors: ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SPTA1 SPTAN1 YWHAQ
Entrez ID		4684	6710
HPRD ID		00301	01686
Ensembl ID		ENSG00000149294	ENSG00000070182
Uniprot IDs		P13591	P11277 Q59FP5 Q86TX9
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR	1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Chemotaxis Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Movement Of Cell Or Subcellular Component Cell Projection Organization Generation Of Neurons Locomotion Neurogenesis Cell Development Response To External Stimulus Anatomical Structure Morphogenesis Nervous System Development System Development Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Developmental Process Single-organism Behavior Ganglioside Biosynthetic Process Response To Stimulus N-glycan Processing Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ganglioside Metabolic Process Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycosphingolipid Biosynthetic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Learning Or Memory Cognition Axon Target Recognition Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Oligosaccharide Metabolic Process	Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Protein Complex Disassembly Negative Regulation Of Protein Complex Assembly Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Cell Differentiation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Axonogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Morphogenesis Axon Development Homeostasis Of Number Of Cells Positive Regulation Of Protein Binding Cell Morphogenesis Involved In Neuron Differentiation Cell Development Developmental Process Actin Cytoskeleton Organization Execution Phase Of Apoptosis Neuron Projection Morphogenesis Actin Filament-based Process Regulation Of Cellular Component Organization System Development Cell Morphogenesis Involved In Differentiation Organelle Organization Erythrocyte Differentiation Regulation Of Actin Cytoskeleton Organization Erythrocyte Homeostasis Neuron Projection Development Multicellular Organismal Development Positive Regulation Of Binding Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Anatomical Structure Development Anatomical Structure Morphogenesis Myeloid Cell Homeostasis Regulation Of Protein Binding
Tagcloud ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 ugt1a1
Tagcloud (Difference) ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 ugt1a1
Tagcloud (Intersection) ?