NCAM1 and SPTB

Number of citations of the paper that reports this interaction (PubMedID 12743109)
55

Data Source:
HPRD (in vitro)

		NCAM1	SPTB
Description		neural cell adhesion molecule 1	spectrin beta, erythrocytic
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Neuron Projection Side Of Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Protein-containing Complex Cell Projection Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Virus Receptor Activity Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Adhesion Symbiont Entry Into Host Cell Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway	Actin Cytoskeleton Organization Synapse Organization Actin Filament Capping Modification Of Postsynaptic Actin Cytoskeleton
Pathways		ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases			Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Age at first sexual intercourse ( 34211149 27089180) Blood protein levels ( 30072576) Body mass index ( 25673413) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Cannabis use ( 27023175 30150663) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) Frailty index ( 34431594) Gastroesophageal reflux disease ( 33608531) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549 28869591) Irritable bowel syndrome ( 33608531) LDL levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 33082346 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878) Total cholesterol levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429)	Daytime sleep phenotypes ( 27126917) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 31049640)
Interacting Genes		19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	18 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN ENO3 EPB41 MAPT NCAM1 NRIP1 SH2D2A SNAPIN SPTA1 SPTAN1 STAT1 TULP3 YWHAQ
Entrez ID		4684	6710
HPRD ID		00301	01686
Ensembl ID		ENSG00000149294	ENSG00000070182
Uniprot IDs		A0A087WWD4 H7BYX6 P13591	P11277
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?		Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sialylation Enzyme-linked Receptor Protein Signaling Pathway Ganglioside Biosynthetic Process Regulation Of Synapse Organization Sialyltransferase Activity N-glycan Processing Sialic Acid Binding Ganglioside Metabolic Process Postsynapse Glycosphingolipid Biosynthetic Process Regulation Of Neuron Apoptotic Process System Development Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Neuron Projection Development Positive Regulation Of Nervous System Development Regulation Of Programmed Cell Death Cell Projection Organization Negative Regulation Of Dendritic Spine Maintenance Developmental Process Plasma Membrane Bounded Cell Projection Organization Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Extrinsic Apoptotic Signaling Pathway Ceramide Biosynthetic Process Glycosphingolipid Metabolic Process Cell Migration Oligosaccharide Metabolic Process Golgi Apparatus Positive Regulation Of Developmental Process Regulation Of Apoptotic Signaling Pathway Salivary Gland Morphogenesis Glycolipid Biosynthetic Process Dendritic Spine Maintenance Regulation Of Multicellular Organismal Process Neuron Projection Guidance Axon Guidance Regulation Of Nervous System Development Regulation Of Developmental Process Membrane Raft Cell Motility Macromolecule Biosynthetic Process Regulation Of Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Protein N-linked Glycosylation Adult Locomotory Behavior	Spectrin-associated Cytoskeleton Cortical Cytoskeleton Spectrin Binding Actin Filament Capping Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Cytosol Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Cytoskeleton Organization Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Cellular Component Size Cytoskeleton Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Organelle Organization Cytoplasm Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Spectrin Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament Binding Cell Junction Negative Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Axolemma Supramolecular Fiber Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Mesenchymal Cell Differentiation Regulation Of Cytoskeleton Organization Cytoskeletal Anchor Activity Protein Phosphatase 2A Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Localization To Cell Periphery Kinesin Binding Axon Substantia Nigra Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Melanosome Organization Pigment Granule Organization
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