NCAM1 and GFRA1

Number of citations of the paper that reports this interaction (PMID 12837245)
69

Data Source:
HPRD (in vivo)

		NCAM1	GFRA1
Gene Name		neural cell adhesion molecule 1	GDNF family receptor alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Identical Protein Binding	Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity
	Biological Process	Cell Adhesion Axon Guidance Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Interferon-gamma-mediated Signaling Pathway	Cell Surface Receptor Signaling Pathway Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		Interferon gamma signaling Signal transduction by L1 NCAM1 interactions Axon guidance ECM proteoglycans Interferon Signaling L1CAM interactions Cytokine Signaling in Immune system NCAM signaling for neurite out-growth	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Entorhinal cortical thickness ( 21116278) Left ventricular mass ( 21212386)
Protein-Protein Interactions		19 interactors: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	6 interactors: GDNF NCAM1 NRTN RET SOCS3 TRADD
Entrez ID		4684	2674
HPRD ID		00301	03291
Ensembl ID		ENSG00000149294	ENSG00000151892
Uniprot IDs		P13591	B7Z856 P56159
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Chemotaxis Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Movement Of Cell Or Subcellular Component Cell Projection Organization Generation Of Neurons Locomotion Neurogenesis Cell Development Response To External Stimulus Anatomical Structure Morphogenesis Nervous System Development System Development Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Developmental Process Single-organism Behavior Ganglioside Biosynthetic Process Response To Stimulus N-glycan Processing Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ganglioside Metabolic Process Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycosphingolipid Biosynthetic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Learning Or Memory Cognition Axon Target Recognition Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Oligosaccharide Metabolic Process	Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Ameboidal-type Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Stem Cell Development Positive Regulation Of Kidney Development Neuron Development Stem Cell Differentiation Autonomic Nervous System Development Anatomical Structure Morphogenesis Neuron Differentiation Axon Guidance Locomotion Signal Transduction Cytokine-mediated Signaling Pathway Morphogenesis Of An Epithelium Signaling Regulation Of Apoptotic Process Axonogenesis Cell Communication Movement Of Cell Or Subcellular Component Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Nerve Development Regulation Of Cell Death Generation Of Neurons Axon Development Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Zymogen Activation Metanephros Development Chemotaxis Neurogenesis Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ureteric Bud Development Neuron Projection Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Development Embryonic Morphogenesis Tissue Morphogenesis Interferon-gamma-mediated Signaling Pathway
Tagcloud ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes
Tagcloud (Difference) ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes
Tagcloud (Intersection) ?