NCAM1

Description		neural cell adhesion molecule 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Neuron Projection Side Of Membrane
	Molecular Function	Virus Receptor Activity Protein Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Adhesion Symbiont Entry Into Host Cell Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149 27089180) Blood protein levels ( 30072576) Body mass index ( 25673413) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Cannabis use ( 27023175 30150663) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) Frailty index ( 34431594) Gastroesophageal reflux disease ( 33608531) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549 28869591) Irritable bowel syndrome ( 33608531) LDL levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 33082346 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878) Total cholesterol levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		4684
HPRD ID		00301
Ensembl ID		ENSG00000149294
Uniprot IDs		A0A087WWD4 H7BYX6 P13591
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN
Enriched GO Terms of Interacting Partners?		Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sialylation Enzyme-linked Receptor Protein Signaling Pathway Ganglioside Biosynthetic Process Regulation Of Synapse Organization Sialyltransferase Activity N-glycan Processing Sialic Acid Binding Ganglioside Metabolic Process Postsynapse Glycosphingolipid Biosynthetic Process Regulation Of Neuron Apoptotic Process System Development Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Neuron Projection Development Positive Regulation Of Nervous System Development Regulation Of Programmed Cell Death Cell Projection Organization Negative Regulation Of Dendritic Spine Maintenance Developmental Process Plasma Membrane Bounded Cell Projection Organization Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Extrinsic Apoptotic Signaling Pathway Ceramide Biosynthetic Process Glycosphingolipid Metabolic Process Cell Migration Oligosaccharide Metabolic Process Golgi Apparatus Positive Regulation Of Developmental Process Regulation Of Apoptotic Signaling Pathway Salivary Gland Morphogenesis Glycolipid Biosynthetic Process Dendritic Spine Maintenance Regulation Of Multicellular Organismal Process Neuron Projection Guidance Axon Guidance Regulation Of Nervous System Development Regulation Of Developmental Process Membrane Raft Cell Motility Macromolecule Biosynthetic Process Regulation Of Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Protein N-linked Glycosylation Adult Locomotory Behavior
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