NCAM1 and ST8SIA2

Number of citations of the paper that reports this interaction (PMID 8702635)
10

Data Source:
HPRD (in vitro)

		NCAM1	ST8SIA2
Gene Name		neural cell adhesion molecule 1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Golgi Membrane Early Endosome Integral Component Of Golgi Membrane Recycling Endosome
	Molecular Function	Identical Protein Binding	Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Sialic Acid Binding
	Biological Process	Cell Adhesion Axon Guidance Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Interferon-gamma-mediated Signaling Pathway	Ganglioside Biosynthetic Process Carbohydrate Metabolic Process Cellular Protein Modification Process Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process N-glycan Processing Nervous System Development Axon Guidance Oligosaccharide Metabolic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation
Pathways		Interferon gamma signaling Signal transduction by L1 NCAM1 interactions Axon guidance ECM proteoglycans Interferon Signaling L1CAM interactions Cytokine Signaling in Immune system NCAM signaling for neurite out-growth	Diseases of glycosylation Axon guidance Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) N-Glycan antennae elongation Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein N-glycan antennae elongation in the medial/trans-Golgi Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 NCAM signaling for neurite out-growth Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) NCAM1 interactions Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Entorhinal cortical thickness ( 21116278) Left ventricular mass ( 21212386)	Airflow obstruction ( 22837378) Bipolar disorder ( 20386566) Weight loss (gastric bypass surgery) ( 23643386)
Protein-Protein Interactions		19 interactors: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	1 interactors: NCAM1
Entrez ID		4684	8128
HPRD ID		00301	03969
Ensembl ID		ENSG00000149294	ENSG00000140557
Uniprot IDs		P13591	B2R9U8 C6G488 Q92186
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Chemotaxis Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Movement Of Cell Or Subcellular Component Cell Projection Organization Generation Of Neurons Locomotion Neurogenesis Cell Development Response To External Stimulus Anatomical Structure Morphogenesis Nervous System Development System Development Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Developmental Process Single-organism Behavior Ganglioside Biosynthetic Process Response To Stimulus N-glycan Processing Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ganglioside Metabolic Process Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycosphingolipid Biosynthetic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Learning Or Memory Cognition Axon Target Recognition Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Oligosaccharide Metabolic Process
Tagcloud ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	7mg appreciably became cannabinoids cannabis cognition consequence consisting delta9 dentate functionally genetically hit juvenile lasting ncam obvious outer plasticity polysialic polysialylation polysialyltransferases predisposed synergistic tetrahydrocannabinol thc variations wildtype
Tagcloud (Difference) ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	7mg appreciably became cannabinoids cannabis cognition consequence consisting delta9 dentate genetically hit juvenile lasting ncam obvious outer plasticity polysialic polysialylation polysialyltransferases predisposed synergistic tetrahydrocannabinol thc variations wildtype
Tagcloud (Intersection) ?		functionally