NCAM1 and GDNF

Number of citations of the paper that reports this interaction (PMID 12837245)
69

Data Source:
HPRD (in vivo)

		NCAM1	GDNF
Gene Name		neural cell adhesion molecule 1	glial cell derived neurotrophic factor
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region
	Molecular Function	Identical Protein Binding	Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Cell Adhesion Axon Guidance Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Interferon-gamma-mediated Signaling Pathway	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Adult Locomotory Behavior Postganglionic Parasympathetic Nervous System Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interferon gamma signaling Signal transduction by L1 NCAM1 interactions Axon guidance ECM proteoglycans Interferon Signaling L1CAM interactions Cytokine Signaling in Immune system NCAM signaling for neurite out-growth	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Entorhinal cortical thickness ( 21116278) Left ventricular mass ( 21212386)	Major depressive disorder ( 20125088)
Protein-Protein Interactions		19 interactors: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	5 interactors: AGTRAP GFRA1 GFRA2 NCAM1 RET
Entrez ID		4684	2668
HPRD ID		00301	02906
Ensembl ID		ENSG00000149294	ENSG00000168621
Uniprot IDs		P13591	P39905
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR	2V5E 3FUB
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Chemotaxis Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Movement Of Cell Or Subcellular Component Cell Projection Organization Generation Of Neurons Locomotion Neurogenesis Cell Development Response To External Stimulus Anatomical Structure Morphogenesis Nervous System Development System Development Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Developmental Process Single-organism Behavior Ganglioside Biosynthetic Process Response To Stimulus N-glycan Processing Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ganglioside Metabolic Process Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycosphingolipid Biosynthetic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Learning Or Memory Cognition Axon Target Recognition Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Oligosaccharide Metabolic Process	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Posterior Midgut Development Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Response To Organic Substance Positive Regulation Of Neuron Maturation Neuron Development Signaling Lymphocyte Migration Into Lymphoid Organs Cell Communication Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Neuron Differentiation Ureter Maturation Regulation Of Neuron Maturation Locomotion Angiotensin-activated Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Movement Of Cell Or Subcellular Component Generation Of Neurons Axon Guidance Enteric Nervous System Development Neurogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Development System Development Midgut Development Axonogenesis Response To Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Autophosphorylation Chemotaxis Neuron Maturation Lymphocyte Migration Multicellular Organismal Development Neuron Projection Morphogenesis
Tagcloud ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc
Tagcloud (Difference) ?		abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc
Tagcloud (Intersection) ?