FZR1 and FBXO5

Number of citations of the paper that reports this interaction (PubMedID 35634770)
54

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		FZR1	FBXO5
Description		fizzy and cell division cycle 20 related 1	F-box protein 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Meiotic Spindle
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Protein Binding Zinc Ion Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Molecular Function Inhibitor Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence	Oocyte Maturation Regulation Of DNA Replication DNA Damage Response Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Meiotic Nuclear Division Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Spindle Assembly Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)
Interacting Genes		95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10	11 interacting genes: ANAPC1 ANAPC11 ANAPC7 CDC20 CDK1 EVI5 FZR1 RAD51 SKP1 SRC TPM3
Entrez ID		51343	26271
HPRD ID		04687	09348
Ensembl ID		ENSG00000105325	ENSG00000112029
Uniprot IDs		Q9UM11	Q9UKT4
PDB IDs		4UI9 5L9T 5L9U 8TAR 8TAU 9GAW	2M6N 4UI9 9GAW
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process	Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Meiotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Proteasomal Protein Catabolic Process Post-translational Protein Modification Protein K11-linked Ubiquitination Regulation Of Chromosome Segregation Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Activator Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Cycle Phase Transition Protein Modification Process Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Modification By Small Protein Conjugation Proteolysis Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cytosol Positive Regulation Of Mitotic Nuclear Division Thymidine Biosynthetic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Thymidine Metabolic Process Cytoskeleton Positive Regulation Of Organelle Organization
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