FZR1 and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FZR1	MAP2K3
Description		fizzy and cell division cycle 20 related 1	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence	MAPK Cascade Regulation Of Cytokine Production Response To Ischemia Inflammatory Response Signal Transduction Heart Development Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Maturation Cardiac Muscle Contraction Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To UV-B Cellular Response To Sorbitol Cellular Senescence Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs			Fostamatinib Pimasertib
Diseases
GWAS		Red cell distribution width ( 32888494)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10	53 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		51343	5606
HPRD ID		04687	03816
Ensembl ID		ENSG00000105325	ENSG00000034152
Uniprot IDs		Q9UM11	P46734 Q6FI23
PDB IDs		4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Kinase Activity Regulation Of Cell Cycle MAP Kinase Kinase Kinase Activity Regulation Of Intracellular Signal Transduction Animal Organ Development Developmental Process Regulation Of Cell Population Proliferation Regulation Of Cellular Component Organization Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Communication Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Cell Differentiation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Cytosol Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Metabolic Process Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Apoptotic Process
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