FZR1 and SKP2

Number of citations of the paper that reports this interaction (PMID 15014503)
119

Data Source:
HPRD (in vitro)

		FZR1	SKP2
Gene Name		fizzy/cell division cycle 20 related 1 (Drosophila)	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle DNA Repair Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Regulation Of Meiosis Positive Regulation Of Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Negative Regulation Of Cell Aging	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Cellular Senescence Phosphorylation of Emi1 Orc1 removal from chromatin Autodegradation of Cdh1 by Cdh1:APC/C Class I MHC mediated antigen processing & presentation Removal of licensing factors from origins Switching of origins to a post-replicative state Synthesis of DNA Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Orc1 removal from chromatin SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Cyclin A:Cdk2-associated events at S phase entry Adaptive Immune System	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ANAPC1 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B C7orf25 CCNA2 CCNB1 CDC14A CDC20 CDC25A CDC27 CDC6 CDK1 CDK2 CDR2 CDT1 CLSPN DNAJA1 E2F3 FBXO5 HECW2 MAK MAPK8 MOAP1 PLK1 PTEN PTTG1 RBBP8 SIRT2 SKIL SKP2 SOX2 TK1 TP53 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2S	54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		51343	6502
HPRD ID		04687	03256
Ensembl ID			ENSG00000145604
Uniprot IDs		Q9UM11	Q13309
PDB IDs			1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Regulation Of Chromosome Segregation Mitotic Nuclear Division Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Division Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Checkpoint Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Cellular Macromolecule Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Chromosome Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process
Tagcloud ?		anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Difference) ?		anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Intersection) ?