GAN

Description		gigaxonin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Cytoskeleton Organization Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Skin and soft tissue infections ( 33662382) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: IRF8
Interacting Genes		4 interacting genes: ATG16L1 MAP1B TBCB UBA1
Entrez ID		8139
HPRD ID		05647
Ensembl ID		ENSG00000261609
Uniprot IDs		A0A0S2Z4W2 B3KTC3 Q9H2C0
PDB IDs		2PPI 3HVE
Enriched GO Terms of Interacting Partners?		Induction Of Synaptic Plasticity By Chemical Substance Vacuole-isolation Membrane Contact Site Post-chaperonin Tubulin Folding Pathway Tubulin Complex Assembly Microtubule-based Process Cytosol Autophagy Plasmacytoid Dendritic Cell Activation Plasmacytoid Dendritic Cell Differentiation Follicular B Cell Differentiation Germinal Center B Cell Differentiation Positive Regulation Of Synaptic Plasticity Varicosity Cell Projection Morphogenesis Response To Insecticide Peripheral Nervous System Axon Regeneration Microtubule-based Transport Odontoblast Differentiation Transport Along Microtubule Neuron Projection Morphogenesis Hippocampal Mossy Fiber Cytoskeleton-dependent Intracellular Transport Basal Dendrite Endosome Membrane Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Ubiquitin Activating Enzyme Activity C-terminal Protein Lipidation Viral RNA Genome Replication Xenophagy Negative Regulation Of Dendrite Extension Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Regulation Of Developmental Growth Dendrite Arborization Microtubule Response To Vitamin A Response To Stress Apical Dendrite Somatodendritic Compartment Microtubule-based Movement Lysosomal Membrane Protein Localization To Phagophore Assembly Site Regulation Of Cell Growth Axon Corpus Callosum Development Endolysosome Membrane Ubiquitin-like Protein Transferase Activity Neuron Projection Arborization Viral Genome Replication
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