GAN and MAP1B

Number of citations of the paper that reports this interaction (PubMedID 12147674)
25

Data Source:
HPRD (in vitro, in vivo)

		GAN	MAP1B
Description		gigaxonin	microtubule associated protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Photoreceptor Outer Segment Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Axon Dendrite Growth Cone Somatodendritic Compartment Cell Projection Neuronal Cell Body Varicosity Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Basal Dendrite Hippocampal Mossy Fiber Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Actin Binding Structural Molecule Activity Protein Binding Phospholipid Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Cytoskeleton Organization Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Negative Regulation Of Microtubule Depolymerization Nervous System Development Axonogenesis Synapse Assembly Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Carbohydrate Peripheral Nervous System Axon Regeneration Dendrite Development Response To Insecticide Developmental Maturation Regulation Of Microtubule Depolymerization Positive Regulation Of Microtubule Polymerization Neuron Projection Development Response To Nutrient Levels Response To Estradiol Negative Regulation Of Intracellular Transport Response To Vitamin A Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Intracellular Transport Mitochondrion Transport Along Microtubule Neuron Development Axon Extension Response To Axon Injury Induction Of Synaptic Plasticity By Chemical Substance Establishment Of Monopolar Cell Polarity Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Odontoblast Differentiation Regulation Of Postsynapse Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	RSV-host interactions
Drugs
Diseases
GWAS		Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Skin and soft tissue infections ( 33662382) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Attention deficit hyperactivity disorder ( 18839057) Coronary artery disease in type 1 diabetes ( 29695241) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: ATG16L1 MAP1B TBCB UBA1	36 interacting genes: ACTB ANP32A ARHGEF11 CREBBP CSNK2A1 DYNLL1 EEF1D ERBB3 FOS GABRR1 GABRR2 GAN GSK3B HMGB1 HTR6 LRRK2 MAG MAGOH MAP1A MAPK8 MARCHF5 MINK1 NEIL3 NXF1 NXF2 PAFAH1B1 PRKAR1A RASSF1 RNF10 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2 VHL
Entrez ID		8139	4131
HPRD ID		05647	01139
Ensembl ID		ENSG00000261609	ENSG00000131711
Uniprot IDs		A0A0S2Z4W2 B3KTC3 Q9H2C0	A2BDK6 P46821 Q6PJD3 Q86X89
PDB IDs		2PPI 3HVE
Enriched GO Terms of Interacting Partners?		Induction Of Synaptic Plasticity By Chemical Substance Vacuole-isolation Membrane Contact Site Post-chaperonin Tubulin Folding Pathway Tubulin Complex Assembly Microtubule-based Process Cytosol Autophagy Plasmacytoid Dendritic Cell Activation Plasmacytoid Dendritic Cell Differentiation Follicular B Cell Differentiation Germinal Center B Cell Differentiation Positive Regulation Of Synaptic Plasticity Varicosity Cell Projection Morphogenesis Response To Insecticide Peripheral Nervous System Axon Regeneration Microtubule-based Transport Odontoblast Differentiation Transport Along Microtubule Neuron Projection Morphogenesis Hippocampal Mossy Fiber Cytoskeleton-dependent Intracellular Transport Basal Dendrite Endosome Membrane Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Ubiquitin Activating Enzyme Activity C-terminal Protein Lipidation Viral RNA Genome Replication Xenophagy Negative Regulation Of Dendrite Extension Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Regulation Of Developmental Growth Dendrite Arborization Microtubule Response To Vitamin A Response To Stress Apical Dendrite Somatodendritic Compartment Microtubule-based Movement Lysosomal Membrane Protein Localization To Phagophore Assembly Site Regulation Of Cell Growth Axon Corpus Callosum Development Endolysosome Membrane Ubiquitin-like Protein Transferase Activity Neuron Projection Arborization Viral Genome Replication	Tau Protein Binding Positive Regulation Of Cell Communication Cellular Response To Stress Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Microtubule Associated Complex Axon Regulation Of Norepinephrine Uptake Regulation Of Biological Quality JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Transporter Regulator Activity Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Localization Negative Regulation Of Gene Expression Synapse Glutamatergic Synapse Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Protein Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Trans-synaptic Signaling Synaptic Signaling Modulation Of Chemical Synaptic Transmission Nuclear RNA Export Factor Complex Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Substantia Nigra Development Regulation Of Apoptotic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process
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