TYRP1 and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 11441007)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TYRP1	GIPC1
Description		tyrosinase related protein 1	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle Bounding Membrane Of Organelle	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Monooxygenase Activity Tyrosinase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding
	Biological Process	Melanin Metabolic Process Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Pigmentation Positive Regulation Of Melanin Biosynthetic Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation	FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling
Drugs
Diseases		Oculocutaneous albinism (OCA)
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 18488028) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eye color ( 23548203 30664655) Eye color (brightness) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 30166351) Hair color ( 22556244 29662168) Low tan response ( 29739929) Metabolite levels ( 23823483) Mild to moderate chronic kidney disease ( 31178898) Mitochondrial DNA copy number ( 30704525) Neuroticism ( 27089181) Nevus count or cutaneous melanoma ( 32341527) Psoriasis ( 30921485) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Skin pigmentation ( 29195075) Smoking status (ever vs never smokers) ( 30643258)	Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)
Interacting Genes		3 interacting genes: GIPC1 SEC22A TYR	37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408
Entrez ID		7306	10755
HPRD ID		00283	05462
Ensembl ID		ENSG00000107165	ENSG00000123159
Uniprot IDs		P17643	A8K2I7 O14908
PDB IDs		5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T 9EY5 9EY6 9EY7 9EY8
Enriched GO Terms of Interacting Partners?		Tyrosinase Activity Eye Pigment Biosynthetic Process Melanin Biosynthetic Process From Tyrosine Pigment Metabolic Process Involved In Pigmentation Melanin Metabolic Process Response To Blue Light Tyrosine Metabolic Process Golgi-associated Vesicle Melanin Biosynthetic Process Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion Melanosome Membrane Myosin Binding Response To Vitamin D Aromatic Amino Acid Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Vesicle Membrane SNAP Receptor Activity Secondary Metabolic Process Dendritic Shaft Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Thymus Development Pigmentation Copper Ion Binding Acidic Amino Acid Transport Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility
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