TYRP1 and TYR

Number of citations: 0 (PubMedID 14623273)
Data Source: HPRD (in vivo)

		TYRP1	TYR
Name		tyrosinase related protein 1	tyrosinase
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle Bounding Membrane Of Organelle	Cytoplasm Lysosome Golgi-associated Vesicle Membrane Melanosome Membrane Melanosome Perinuclear Region Of Cytoplasm
	Molecular Function	Monooxygenase Activity Tyrosinase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Monooxygenase Activity Tyrosinase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Melanin Metabolic Process Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Pigmentation Positive Regulation Of Melanin Biosynthetic Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP
Pathways		Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation	Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation
Drugs		None	NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases		Oculocutaneous albinism (OCA)	Oculocutaneous albinism (OCA)
GWAS		Adult body size ( 32376654 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blond vs. brown/black hair color ( 30531825 ) Blue vs. green eyes ( 18488028 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous melanoma or hair colour ( 32341527 ) Cutaneous squamous cell carcinoma ( 32041948 ) Eye color ( 23548203 30664655 ) Eye color (brightness) ( 30664655 ) Eye color (saturation) ( 30664655 ) Eye color traits ( 30166351 ) Hair color ( 22556244 29662168 ) Low tan response ( 29739929 ) Metabolite levels ( 23823483 ) Mild to moderate chronic kidney disease ( 31178898 ) Mitochondrial DNA copy number ( 30704525 ) Neuroticism ( 27089181 ) Nevus count or cutaneous melanoma ( 32341527 ) Psoriasis ( 30921485 ) Refractive error ( 32231278 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Skin pigmentation ( 29195075 ) Smoking status (ever vs never smokers) ( 30643258 )	Age-related hearing impairment ( 34108613 ) Age-related macular degeneration ( 23326517 ) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Basal cell carcinoma ( 33549134 27539887 31174203 ) Blond vs. brown/black hair color ( 30531825 ) Blue vs. green eyes ( 17952075 ) Brown vs. black hair color ( 30531825 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous melanoma or hair colour ( 32341527 ) Cutaneous squamous cell carcinoma ( 27424798 32041948 ) Eye color ( 20585627 ) Eye color (brightness) ( 30664655 ) Fish- and plant-related diet ( 32066663 ) Freckles ( 17952075 ) Hair color ( 26926045 30664655 29662168 ) Intraocular pressure ( 29617998 ) Keratinocyte cancer (MTAG) ( 31174203 ) Low tan response ( 29739929 ) Macular thickness ( 30535121 ) Melanoma ( 19578364 21983787 24980573 28212542 ) Neurociticism ( 29500382 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Non-melanoma skin cancer ( 29739929 ) Optic disc size ( 31809533 ) Skin pigmentation ( 31315583 30664655 17999355 ) Skin pigmentation traits ( 30166351 ) Skin sensitivity to sun ( 17952075 ) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655 ) Squamous cell carcinoma ( 31174203 26829030 ) Sunburns ( 23548203 ) Tanning ( 23548203 19340012 ) Vitiligo ( 22561518 20410501 27723757 )
Novel Interactors		None recorded	2 novel interactors: PRICKLE1 UBASH3A
Interacting Genes		3 interacting genes: GIPC1 SEC22A TYR	1 interacting genes: TYRP1
Entrez ID		7306	7299
HPRD ID		00283	06086
Ensembl ID		ENSG00000107165	ENSG00000077498
Uniprot IDs		P17643	L8B082 P14679
PDB IDs		5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T 9EY5 9EY6 9EY7 9EY8	7RK7
GO Terms Enriched among Interactors		Tyrosinase Activity Eye Pigment Biosynthetic Process Melanin Biosynthetic Process From Tyrosine Pigment Metabolic Process Involved In Pigmentation Melanin Metabolic Process Response To Blue Light Tyrosine Metabolic Process Golgi-associated Vesicle Melanin Biosynthetic Process Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion Melanosome Membrane Myosin Binding Response To Vitamin D Aromatic Amino Acid Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Vesicle Membrane SNAP Receptor Activity Secondary Metabolic Process Dendritic Shaft Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Thymus Development Pigmentation Copper Ion Binding Acidic Amino Acid Transport Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Acetoacetic Acid Metabolic Process Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Tyrosinase Activity Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Extracellular Matrix Constituent Secretion Tear Secretion Embryonic Nail Plate Morphogenesis Maintenance Of Postsynaptic Density Structure Ketone Body Metabolic Process Positive Regulation Of Melanin Biosynthetic Process Maintenance Of Postsynaptic Specialization Structure Cornea Development In Camera-type Eye Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Melanin Biosynthetic Process Primitive Streak Formation Eyelid Development In Camera-type Eye Negative Regulation Of Cardiocyte Differentiation Melanocyte Differentiation Short-chain Fatty Acid Metabolic Process Bounding Membrane Of Organelle Intracellular Vesicle Post-anal Tail Morphogenesis Embryonic Brain Development Regulation Of Postsynaptic Specialization Assembly Regulation Of Postsynaptic Density Assembly Regulation Of Excitatory Synapse Assembly Postsynaptic Density Organization Pigment Cell Differentiation Melanosome Membrane Postsynaptic Specialization Organization Negative Regulation Of Stem Cell Differentiation Renal Tubule Development Coronary Vasculature Development Negative Regulation Of T Cell Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Maintenance Of Synapse Structure Aorta Development Extracellular Matrix Assembly Basement Membrane Organization Negative Regulation Of Myoblast Differentiation Face Morphogenesis Melanosome Organization Pigment Granule Organization Response To Electrical Stimulus Cardiac Muscle Cell Development