TYRP1 and TYR

Number of citations of the paper that reports this interaction (PMID 14623273)
2

Data Source:
HPRD (in vivo)

		TYRP1	TYR
Gene Name		tyrosinase-related protein 1	tyrosinase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome	Cytoplasm Lysosome Golgi-associated Vesicle Integral Component Of Membrane Melanosome Membrane Melanosome Perinuclear Region Of Cytoplasm
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Another Compound As One Donor, And Incorporation Of One Atom Of Oxygen Protein Homodimerization Activity Protein Heterodimerization Activity	Monophenol Monooxygenase Activity Copper Ion Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Oxidation-reduction Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Proliferation Thymus Development Oxidation-reduction Process
Pathways
Drugs			NADH Azelaic Acid Monobenzone Mimosine
Diseases
GWAS		Blue vs. green eyes ( 18488028) Eye color ( 23548203) Hair color ( 22556244)	Age-related macular degeneration ( 23326517) Blue vs. green eyes ( 17952075) Eye color ( 20585627) Freckles ( 17952075) Melanoma ( 21983787 19578364) Skin pigmentation ( 17999355) Skin sensitivity to sun ( 17952075) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 22561518)
Protein-Protein Interactions		2 interactors: GIPC1 TYR	1 interactors: TYRP1
Entrez ID		7306	7299
HPRD ID		00283	06086
Ensembl ID		ENSG00000107165	ENSG00000077498
Uniprot IDs		P17643	L8B082 P14679
PDB IDs
Enriched GO Terms of Interacting Partners?		Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Eye Pigmentation Tyrosine Metabolic Process Melanin Biosynthetic Process Melanin Metabolic Process Glutamate Secretion Secondary Metabolite Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokinesis Aromatic Amino Acid Family Metabolic Process Acid Secretion Regulation Of Cytokinesis Thymus Development Pigment Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Developmental Pigmentation Negative Regulation Of Cellular Protein Catabolic Process Endothelial Cell Migration Dicarboxylic Acid Transport Epithelial Cell Migration Phenol-containing Compound Metabolic Process Epithelium Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Pigmentation Positive Regulation Of Cell Division Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amino Acid Transport Regulation Of Synaptic Plasticity Visual Perception Sensory Perception Of Light Stimulus Ameboidal-type Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Proteasomal Protein Catabolic Process	Acetoacetic Acid Metabolic Process Short-chain Fatty Acid Metabolic Process Melanin Biosynthetic Process Melanin Metabolic Process Melanosome Organization Secondary Metabolite Biosynthetic Process Pigment Granule Organization Melanocyte Differentiation Neuroepithelial Cell Differentiation Pigment Biosynthetic Process Cellular Pigmentation Developmental Pigmentation Phenol-containing Compound Metabolic Process Pigmentation Vesicle Organization Fatty Acid Metabolic Process Epithelial Cell Differentiation Monocarboxylic Acid Metabolic Process
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3	5b carcinogens coactivator competition cooh cos delta12 deoxy genotoxic gh hormonal indirect j2 janus pd98059 peroxisome ppar pparalpha prolactin proliferator prostaglandin reconstituted stat1 stat5b structurally supershift talk transcriptionally transducer
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3	5b carcinogens coactivator competition cooh cos delta12 deoxy genotoxic gh hormonal indirect j2 janus pd98059 peroxisome ppar pparalpha prolactin proliferator prostaglandin reconstituted stat1 stat5b structurally supershift talk transcriptionally transducer
Tagcloud (Intersection) ?