TYRP1

Name	tyrosinase related protein 1
Structure
Interactors	3 interactors: GIPC1 SEC22A TYR
GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle Bounding Membrane Of Organelle
	Molecular Function	Monooxygenase Activity Tyrosinase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Melanin Metabolic Process Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Pigmentation Positive Regulation Of Melanin Biosynthetic Process
Pathways	Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation
Diseases	Oculocutaneous albinism (OCA)
GWAS	Adult body size ( 32376654 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blond vs. brown/black hair color ( 30531825 ) Blue vs. green eyes ( 18488028 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous melanoma or hair colour ( 32341527 ) Cutaneous squamous cell carcinoma ( 32041948 ) Eye color ( 23548203 30664655 ) Eye color (brightness) ( 30664655 ) Eye color (saturation) ( 30664655 ) Eye color traits ( 30166351 ) Hair color ( 22556244 29662168 ) Low tan response ( 29739929 ) Metabolite levels ( 23823483 ) Mild to moderate chronic kidney disease ( 31178898 ) Mitochondrial DNA copy number ( 30704525 ) Neuroticism ( 27089181 ) Nevus count or cutaneous melanoma ( 32341527 ) Psoriasis ( 30921485 ) Refractive error ( 32231278 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Skin pigmentation ( 29195075 ) Smoking status (ever vs never smokers) ( 30643258 )
Entrez ID	7306
HPRD ID	00283
Ensembl ID	ENSG00000107165
Uniprot IDs	P17643
PDB IDs	5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T 9EY5 9EY6 9EY7 9EY8
GO Terms Enriched among Interactors ?	Tyrosinase Activity Eye Pigment Biosynthetic Process Melanin Biosynthetic Process From Tyrosine Pigment Metabolic Process Involved In Pigmentation Melanin Metabolic Process Response To Blue Light Tyrosine Metabolic Process Golgi-associated Vesicle Melanin Biosynthetic Process Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion Melanosome Membrane Myosin Binding Response To Vitamin D Aromatic Amino Acid Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Vesicle Membrane SNAP Receptor Activity Secondary Metabolic Process Dendritic Shaft Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Thymus Development Pigmentation Copper Ion Binding Acidic Amino Acid Transport Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process