DHX38 and AARS1

Data Source: HiPPIP (Novel)

		DHX38	AARS1
Name		DEAH-box helicase 38	alanyl-tRNA synthetase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Ser-tRNA(Ala) Deacylase Activity Nucleic Acid Binding RNA Binding Aminoacyl-tRNA Ligase Activity Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding Amino Acid Binding Ligase Activity Metal Ion Binding Peptide Lactyltransferase (ATP-dependent) Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	TRNA Modification Translation TRNA Aminoacylation For Protein Translation Alanyl-tRNA Aminoacylation TRNA Processing Cerebellar Purkinje Cell Layer Development DNA Damage Response, Signal Transduction By P53 Class Mediator Hippo Signaling Positive Regulation Of Hippo Signaling TRNA Aminoacylation Negative Regulation Of Neuron Apoptotic Process Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Regulation Of Cytoplasmic Translational Fidelity Negative Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Cytosolic tRNA aminoacylation
Drugs		None	Alanine
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Blood protein levels ( 23696881 ) Cholesterol, total ( 20686565 25961943 ) Coronary artery disease ( 29212778 ) Depression ( 29700475 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) LDL cholesterol ( 20686565 25961943 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 22916037 ) Red blood cell count ( 32888494 ) Serum metabolite levels (CMS) ( 31636271 ) Urate levels ( 31578528 )	No GWAS studies recorded
Novel Interactors		9 novel interactors: AARS1 ACTL7B BCO1 CMTM3 CTCF E2F4 NDRG4 NOL3 TNFRSF4	1 novel interactors: DHX38
Interacting Genes		8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C RNF10 SNRNP200 U2AF1 WBP4	6 interacting genes: CDC42 CEBPA EEF1B2 HUNK LINC01554 SUMO2
Entrez ID		9785	16
HPRD ID		05720	03042
Ensembl ID		ENSG00000140829	ENSG00000090861
Uniprot IDs		Q92620	A0A6Q8PH44 P49588
PDB IDs		5YZG 6ZYM 7A5P 8I0W	4XEM 4XEO 5KNN 5T5S 5T76 5V59
GO Terms Enriched among Interactors		MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing U2-type Precatalytic Spliceosome RNA Metabolic Process Nucleic Acid Metabolic Process Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Binding Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Muscle Atrophy Chromatin Loop Anchoring Activity Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Vitamin A Biosynthetic Process Beta-carotene Metabolic Process Nucleus Peptide Lactyltransferase (ATP-dependent) Activity Macromolecule Metabolic Process Ser-tRNA(Ala) Deacylase Activity Cis Assembly Of Pre-catalytic Spliceosome Carotene Metabolic Process Carotenoid Dioxygenase Activity Carotene Catabolic Process Nucleic Acid Binding	None