DHX38

Name	DEAH-box helicase 38
Structure
Novel Interactors	9 novel interactors: AARS1 ACTL7B BCO1 CMTM3 CTCF E2F4 NDRG4 NOL3 TNFRSF4
Interactors	8 interactors: CDC40 CSNK2A1 MFAP1 PPP4C RNF10 SNRNP200 U2AF1 WBP4
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Blood protein levels ( 23696881 ) Cholesterol, total ( 20686565 25961943 ) Coronary artery disease ( 29212778 ) Depression ( 29700475 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) LDL cholesterol ( 20686565 25961943 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 22916037 ) Red blood cell count ( 32888494 ) Serum metabolite levels (CMS) ( 31636271 ) Urate levels ( 31578528 )
Entrez ID	9785
HPRD ID	05720
Ensembl ID	ENSG00000140829
Uniprot IDs	Q92620
PDB IDs	5YZG 6ZYM 7A5P 8I0W
GO Terms Enriched among Interactors ?	MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing U2-type Precatalytic Spliceosome RNA Metabolic Process Nucleic Acid Metabolic Process Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Binding Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Muscle Atrophy Chromatin Loop Anchoring Activity Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Vitamin A Biosynthetic Process Beta-carotene Metabolic Process Nucleus Peptide Lactyltransferase (ATP-dependent) Activity Macromolecule Metabolic Process Ser-tRNA(Ala) Deacylase Activity Cis Assembly Of Pre-catalytic Spliceosome Carotene Metabolic Process Carotenoid Dioxygenase Activity Carotene Catabolic Process Nucleic Acid Binding