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DHX38 and PPP4C
Number of citations of the paper that reports this interaction (PMID
18715871
)
21
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
DHX38
PPP4C
Gene Name
DEAH (Asp-Glu-Ala-His) box polypeptide 38
protein phosphatase 4, catalytic subunit
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Catalytic Step 2 Spliceosome
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Plasma Membrane
Protein Phosphatase 4 Complex
Molecular Function
ATP-dependent RNA Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
NF-kappaB-inducing Kinase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Metal Ion Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription From RNA Polymerase II Promoter
Termination Of RNA Polymerase II Transcription
MRNA Export From Nucleus
RNA Splicing
Gene Expression
MRNA 3'-end Processing
Regulation Of Double-strand Break Repair Via Homologous Recombination
Dephosphorylation
NIK/NF-kappaB Signaling
Pathways
mRNA Splicing
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
Transport of Mature Transcript to Cytoplasm
Cleavage of Growing Transcript in the Termination Region
RNA Polymerase II Transcription Termination
mRNA 3'-end processing
Drugs
Diseases
GWAS
Cholesterol, total (
20686565
)
LDL cholesterol (
20686565
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
6 interactors:
CDC40
CSNK2A1
MFAP1
PPP4C
TERF2IP
U2AF1
20 interactors:
CCDC6
DHX38
HDAC3
IGBP1
JUN
NFKB1
PPP2R1A
PPP2R5D
PPP4R1
PPP4R2
PPP4R4
REL
RELA
SMEK2
TIPRL
TK1
TMSB4X
TP53
TRAF6
TRIM28
Entrez ID
9785
5531
HPRD ID
05720
03615
Ensembl ID
ENSG00000140829
ENSG00000149923
Uniprot IDs
Q92620
P60510
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of Double-strand Break Repair
Termination Of RNA Polymerase II Transcription
Regulation Of DNA Repair
MRNA Export From Nucleus
Regulation Of DNA Recombination
DNA-templated Transcription, Termination
RNA Export From Nucleus
MRNA 3'-end Processing
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Recombination At Telomere
RNA 3'-end Processing
Nuclear Export
MRNA Transport
Regulation Of Response To DNA Damage Stimulus
RNA Transport
RNA Localization
Regulation Of Chromosome Organization
Transcription, DNA-templated
Protection From Non-homologous End Joining At Telomere
RNA Biosynthetic Process
MRNA Splicing, Via Spliceosome
Telomere Capping
Protein Localization To Chromosome, Telomeric Region
RNA Splicing, Via Transesterification Reactions
Nucleocytoplasmic Transport
Nuclear Transport
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
RNA Splicing
RNA Metabolic Process
MRNA Processing
Regulation Of Telomere Maintenance
Gene Expression
RNA-dependent DNA Replication
Negative Regulation Of DNA Recombination
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
MRNA Metabolic Process
Protein Localization To Chromosome
Telomere Maintenance Via Telomere Lengthening
RNA Processing
Mitotic Spindle Checkpoint
NIK/NF-kappaB Signaling
Negative Regulation Of Chromosome Segregation
Cytoplasmic Transport
Spindle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Interleukin-12 Biosynthetic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cellular Metabolic Process
Response To Growth Factor
Toll-like Receptor Signaling Pathway
Positive Regulation Of Interleukin-12 Biosynthetic Process
NIK/NF-kappaB Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Negative Regulation Of Transcription, DNA-templated
Activation Of Innate Immune Response
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Interleukin-12 Production
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Innate Immune Response
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cell Death
Regulation Of Catalytic Activity
Response To Interleukin-1
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin Signaling Pathway
Response To Organic Substance
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Innate Immune Response
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Regulation Of Cytokine Biosynthetic Process
Innate Immune Response
Immune System Process
Membrane Protein Proteolysis
Transcription From RNA Polymerase II Promoter
Immune Response
Tagcloud
?
6j
acpp
canonical
carcinogenic
cdk5
delineate
e2f6
elf1
glands
gprc5a
hindered
ingenuity
ionizing
ipa
map2
mapk12
mapped
microarray
nab2
persistently
perturbed
plcg1
radiation
runx1
scarcity
sema4d
stathmin1
surgically
undertook
Tagcloud (Difference)
?
6j
acpp
canonical
carcinogenic
cdk5
delineate
e2f6
elf1
glands
gprc5a
hindered
ingenuity
ionizing
ipa
map2
mapk12
mapped
microarray
nab2
persistently
perturbed
plcg1
radiation
runx1
scarcity
sema4d
stathmin1
surgically
undertook
Tagcloud (Intersection)
?