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GLIS3
Description
GLIS family zinc finger 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Alzheimer's disease biomarkers (
23562540
)
Anxiety (
33859377
)
Appendicular lean mass (
33097823
)
Blood sugar levels (
29403010
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
29760442
32528159
)
Cerebrospinal P-tau181p levels (
28247064
)
Cerebrospinal T-tau levels (
28247064
)
Chin dimples (
27182965
)
Chronic obstructive pulmonary disease (
30804561
)
Circulating leptin levels or type 2 diabetes (
32341051
)
Fasting blood glucose (
25631608
33842983
22581228
20081858
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fasting glucose (
34059833
)
Fasting insulin (
34059833
)
Fasting plasma glucose (
25187374
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Glaucoma (primary angle closure) (
27064256
)
Height (
28552196
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Homeostasis model assessment of beta-cell function (
20081858
)
Intraocular pressure (
30591961
30054594
29785010
29617998
29235454
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Low hand grip strength (60 years and older) (FNIH) (
33510174
)
Low high density lipoprotein cholesterol levels (
26879886
)
Lung function (FEV1) (
28166213
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Metabolite levels (
23823483
)
Methotrexate pharmacokinetics (acute lymphoblastic leukemia) (
19901119
)
Monocyte count (
32888494
)
Neurociticism (
29500382
)
Nicotine dependence (
28440896
)
Non-HDL cholesterol levels (
32902719
)
Offspring birth weight (
31043758
)
Osteoarthritis of the hip or knee (
29436472
)
Osteoarthritis of the hip or knee (with total joint replacement) (
29436472
)
Peak expiratory flow (
30804560
)
Peginterferon alfa-2a treatment response in chronic hepatitis B infection (
30972912
)
Platelet count (
32888494
)
Red blood cell count (
27863252
32888494
)
Refractive error (
32231278
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Spontaneous preterm birth (preterm delivery) (
25599974
)
Squamous cell lung carcinoma (
28604730
)
Systolic blood pressure (
30224653
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Total cholesterol levels (
32902719
)
Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Type 1 diabetes (
25751624
33830302
19430480
18840781
)
Type 2 diabetes (
24509480
32499647
26818947
22961080
30718926
30297969
22885922
22158537
30054458
28869590
)
Vaginal microbiome composition (community state type) (
32723796
)
White blood cell count (
32888494
)
Interacting Genes
14 interacting genes:
BAG3
CIB1
CLNK
ENO1
ITCH
KRTAP6-1
NEK6
SUFU
TRAF1
TRIB3
TRIP6
TSG101
UBC
YAP1
Entrez ID
169792
HPRD ID
13582
Ensembl ID
ENSG00000107249
Uniprot IDs
A0A0S2Z689
Q1PHJ8
Q8NEA6
PDB IDs
Enriched GO Terms of Interacting Partners
?
Transcription Corepressor Activity
Ubiquitin Protein Ligase Binding
Regulation Of Cell Growth
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Cell Death
Programmed Cell Death
Apoptotic Process
Regulation Of Growth
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Canonical Glycolysis
Regulation Of Protein Serine/threonine Kinase Activity
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Glycolytic Process Through Glucose-6-phosphate
Glycolytic Process Through Fructose-6-phosphate
Protein Serine/threonine Kinase Inhibitor Activity
Glucose Catabolic Process
Regulation Of Protein Localization To Nucleus
Cytokine-mediated Signaling Pathway
Positive Regulation Of Protein Localization
Negative Regulation Of Apoptotic Process
ADP Catabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Magnesium Ion Binding
Purine Ribonucleoside Diphosphate Catabolic Process
Cytoplasm
Negative Regulation Of Transcription By RNA Polymerase II
Glycolytic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Transcription Corepressor Binding
Regulation Of Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Regulation Of Establishment Of Protein Localization
Regulation Of Protein Localization
Enterocyte Differentiation
Positive Regulation Of Male Germ Cell Proliferation
Regulation Of Cellular Response To Drug
Positive Regulation Of Cellular Response To Drug
Ribonucleoside Diphosphate Catabolic Process
Negative Regulation Of Fat Cell Differentiation
ADP Metabolic Process
Regulation Of Phosphorus Metabolic Process
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