GLIS3

Gene Name		GLIS family zinc finger 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23562540) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Methotrexate phramacokinetics (acute lymphoblastic leukemia) ( 19901119) Thyroid hormone levels ( 23408906) Type 1 diabetes ( 19430480 18840781) Type 2 diabetes ( 22961080 22158537)
Protein-protein Interactions		1 interactors: SUFU
Entrez ID		169792
HPRD ID		13582
Ensembl ID		ENSG00000107249
Uniprot IDs		Q1PHJ8 Q8NEA6
PDB IDs
Enriched GO Terms of Interacting Partners?		Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Ventral Spinal Cord Interneuron Differentiation Cytoplasmic Sequestering Of Transcription Factor Cytoplasmic Sequestering Of Protein Negative Regulation Of Embryonic Development Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Spinal Cord Motor Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription Factor Import Into Nucleus Ventral Spinal Cord Development Heart Looping Determination Of Heart Left/right Asymmetry Cell Differentiation In Spinal Cord Embryonic Heart Tube Morphogenesis Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Ossification Neuron Fate Commitment Negative Regulation Of Protein Localization To Nucleus Embryonic Heart Tube Development Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Fate Specification Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Ubiquitination Neural Tube Closure Spinal Cord Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Regulation Of Embryonic Development Negative Regulation Of Intracellular Transport Smoothened Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Dorsal/ventral Pattern Formation Neural Tube Formation Regulation Of Osteoblast Differentiation Maintenance Of Protein Location In Cell Embryonic Epithelial Tube Formation
Tagcloud ?		abated associate cbp coregulators creb detail duodenal fibrosarcoma glisbs homeobox homolog ins interfering kruppel maf mafa musculoaponeurotic neurod1 oncogene pancreatic pdx1 pivotal preproinsulin respective scaffold stabilizes stably synergistic