GLIS3 and YAP1

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		GLIS3	YAP1
Description		GLIS family zinc finger 3	Yes1 associated transcriptional regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Female Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction TEAD-YAP Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Blastocyst Development Trophectodermal Cell Differentiation Tissue Homeostasis Glandular Epithelial Cell Differentiation Heart Process Embryonic Heart Tube Morphogenesis DNA Damage Response Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Cell Growth Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Notochord Development Response To Progesterone Somatic Stem Cell Population Maintenance Organ Growth Hippo Signaling Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Intestinal Epithelial Cell Development Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Tissue Regeneration Canonical Glycolysis Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Positive Regulation Of Stem Cell Population Maintenance Enterocyte Differentiation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of axial mesoderm Zygotic genome activation (ZGA) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)
GWAS		Alzheimer's disease biomarkers ( 23562540) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Blood sugar levels ( 29403010) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442 32528159) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood glucose ( 25631608 33842983 22581228 20081858) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Fasting plasma glucose ( 25187374) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Glaucoma (primary angle closure) ( 27064256) Height ( 28552196) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Homeostasis model assessment of beta-cell function ( 20081858) Intraocular pressure ( 30591961 30054594 29785010 29617998 29235454) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Low high density lipoprotein cholesterol levels ( 26879886) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Methotrexate pharmacokinetics (acute lymphoblastic leukemia) ( 19901119) Monocyte count ( 32888494) Neurociticism ( 29500382) Nicotine dependence ( 28440896) Non-HDL cholesterol levels ( 32902719) Offspring birth weight ( 31043758) Osteoarthritis of the hip or knee ( 29436472) Osteoarthritis of the hip or knee (with total joint replacement) ( 29436472) Peak expiratory flow ( 30804560) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 32888494) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spontaneous preterm birth (preterm delivery) ( 25599974) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Total cholesterol levels ( 32902719) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 1 diabetes ( 25751624 33830302 19430480 18840781) Type 2 diabetes ( 24509480 32499647 26818947 22961080 30718926 30297969 22885922 22158537 30054458 28869590) Vaginal microbiome composition (community state type) ( 32723796) White blood cell count ( 32888494)	Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 26416764 30566500) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		14 interacting genes: BAG3 CIB1 CLNK ENO1 ITCH KRTAP6-1 NEK6 SUFU TRAF1 TRIB3 TRIP6 TSG101 UBC YAP1	103 interacting genes: ABL1 AKT1 AMOT ANK3 APC2 ARID2 ATN1 BEAN1 CCDC87 CDIP1 CNKSR2 CRTC3 CSNK1D CSNK1E DDN EIF3H ENAH ENTREP3 ERBB4 ESS2 FBXW7 FOXI1 FOXJ3 FXR1 GAB1 GAS5 GBF1 GLIS3 HNRNPU HNRNPUL1 IGSF9B JCAD JOSD2 KIF5A LATS2 LINC00839 MAP2 MAP3K2 MAP3K3 MAPKAPK5 MLANA MRPL49 MYCT1 NDFIP2 NEK1 NFE2 NHERF1 NR1I2 OTUB1 OTUD1 PIP4P1 PIP4P2 PKNOX2 PRR7 PRRG2 PRRG4 PTCH1 PTEN PTPN21 RBM14 RHBDD2 RNF11 RNF38 RUNX1 RUNX2 RUNX3 SCAMP3 SCAMP4 SCN1A SDCBP SH3D21 SHISA4 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TGFB1I1 TMEM139 TMEM151B TMEM252 TMEM59L TMEM61 TMEM92 TNRC18 TP53BP2 TP63 TP73 TRERF1 TRIP6 TSPYL2 TTYH3 UBE2L6 UCHL3 UVRAG WBP1 WBP2 WT1 YWHAG YWHAQ YWHAZ
Entrez ID		169792	10413
HPRD ID		13582	09424
Ensembl ID		ENSG00000107249	ENSG00000137693
Uniprot IDs		A0A0S2Z689 Q1PHJ8 Q8NEA6	K0KVU2 P46937
PDB IDs			1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X 7O07 8A8Q 8A8R 8C2F 8WRG 9FZA
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Ubiquitin Protein Ligase Binding Regulation Of Cell Growth Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Cell Death Programmed Cell Death Apoptotic Process Regulation Of Growth Negative Regulation Of Cell Communication Negative Regulation Of Signaling Canonical Glycolysis Regulation Of Protein Serine/threonine Kinase Activity Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Protein Serine/threonine Kinase Inhibitor Activity Glucose Catabolic Process Regulation Of Protein Localization To Nucleus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Localization Negative Regulation Of Apoptotic Process ADP Catabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Magnesium Ion Binding Purine Ribonucleoside Diphosphate Catabolic Process Cytoplasm Negative Regulation Of Transcription By RNA Polymerase II Glycolytic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Enterocyte Differentiation Positive Regulation Of Male Germ Cell Proliferation Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Fat Cell Differentiation ADP Metabolic Process Regulation Of Phosphorus Metabolic Process	WW Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Organ Growth Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of Developmental Growth Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Regulation Of Growth Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Gene Expression Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Communication Protein Phosphorylation Regulation Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Protein Domain Specific Binding Golgi Localization
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