TRPC1 and RHOA

Number of citations of the paper that reports this interaction (PubMedID 12766172)
0

Data Source:
HPRD (in vivo, in vitro)

		TRPC1	RHOA
Description		transient receptor potential cation channel subfamily C member 1	ras homolog family member A
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cation Channel Complex Receptor Complex	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Membrane Lamellipodium Cell Junction Dendrite Midbody Secretory Granule Membrane Vesicle Cleavage Furrow Ruffle Membrane Cell Projection Dendritic Spine Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Transmembrane Transporter Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding Protein Kinase Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Melanin Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Conduction	Mitotic Cytokinesis Cell Morphogenesis Neuron Migration Kidney Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Alpha-beta T Cell Lineage Commitment Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Formation Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Cell Adhesion Cell-matrix Adhesion Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Skeletal Muscle Tissue Development Negative Regulation Of Cell-substrate Adhesion Regulation Of Neuron Projection Development Cell Migration Substantia Nigra Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Actin Cytoskeleton Organization Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Androgen Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Osteoblast Proliferation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Stress Fiber Assembly Apical Junction Assembly Beta Selection Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Size Positive Regulation Of Alpha-beta T Cell Differentiation Negative Chemotaxis Cell Division Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Bone Trabecula Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Negative Regulation Of Oxidative Phosphorylation Motor Neuron Apoptotic Process Endothelial Tube Lumen Extension Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cleavage Furrow Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of T Cell Migration Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		TRP channels Role of second messengers in netrin-1 signaling Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOC GTPase cycle
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 28714974 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		14 interacting genes: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5	124 interacting genes: AGAP1 AGAP2 AKAP13 ANKS1B ARAP2 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP26 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP40 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF5 BCR BIRC2 BMAL1 CAV1 CEBPA CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DLC1 DOCK7 DVL2 FLNA FMN2 GMIP HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 LRP2 LUC7L2 MCF2 MCF2L MPRIP MYO9A NET1 NGEF NOTCH1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PLEKHG4 PLEKHG6 PPP1R12A PREX1 PREX2 PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASGRF2 RASSF1 RHPN1 RHPN2 RIPOR2 ROCK1 RPN2 RTKN SH3BP1 SLC13A1 SMAD2 SMURF1 SNCA SPRED2 SRGAP1 STARD8 TGFBR1 TGM2 TIAM1 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3
Entrez ID		7220	387
HPRD ID		11894	01323
Ensembl ID		ENSG00000144935	ENSG00000067560
Uniprot IDs		P48995	A0A024R324 A0A7I2YQV1 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0
PDB IDs		8WPL 8WPM	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6KX2 6KX3 6R3V 6V6M 6V6U 6V6V 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 7QSC 7QTM 7WZA 7WZC 8BNT 8FC7 8FC9 8FCB 8FPW 8FPX 8GI3 8GI6 8JVJ 8T1C 9AX5
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Calcium Ion Transport Cation Channel Complex Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Response To Calcium Ion Store-operated Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Metal Ion Monoatomic Ion Transport Metal Ion Transport Plasma Membrane Intracellular Calcium Ion Homeostasis Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Regulation Of Calcium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Dendrite Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity G Protein-coupled Glutamate Receptor Binding Transmembrane Transporter Binding Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Muscle Tissue Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Metal Ion Transport Endoplasmic Reticulum Membrane Calcium-mediated Signaling Glutamate Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Transmembrane Transport Intracellular Monoatomic Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Neuron Spine Regulation Of Vasoconstriction Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Caveola Intracellular Signaling Cassette Chemical Homeostasis Signal Transduction ATPase Binding Postsynaptic Density	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction GTPase Activator Activity Guanyl-nucleotide Exchange Factor Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Cytosol Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Rho Protein Signal Transduction Small GTPase Binding Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Cytoplasm Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Cell Migration Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoskeleton Organization Regulation Of Actin Filament Organization Cell Projection Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Organelle Organization Cell Motility Regulation Of Stress Fiber Assembly Positive Regulation Of Small GTPase Mediated Signal Transduction Anchoring Junction Regulation Of GTPase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Rho GDP-dissociation Inhibitor Activity Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Inhibitor Activity Cell Projection Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction
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