TRPC1 and TRPC5

Number of citations of the paper that reports this interaction (PubMedID 12032305)
37

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo)

		TRPC1	TRPC5
Description		transient receptor potential cation channel subfamily C member 1	transient receptor potential cation channel subfamily C member 5
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cation Channel Complex Receptor Complex	Plasma Membrane Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Presynapse
	Molecular Function	Signaling Receptor Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Transmembrane Transporter Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Actin Binding Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Melanin Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Conduction	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization
Pathways		TRP channels Role of second messengers in netrin-1 signaling Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS			Smoking behavior ( 19247474)
Interacting Genes		14 interacting genes: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5	9 interacting genes: DRD2 ENKUR ITPR3 MX1 NHERF1 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		7220	7224
HPRD ID		11894	02273
Ensembl ID		ENSG00000144935	ENSG00000072315
Uniprot IDs		P48995	Q9UL62
PDB IDs		8WPL 8WPM	6YSN 7D4P 7D4Q 7E4T 7WDB 7X6C 7X6I 8GVW 8GVX
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Calcium Ion Transport Cation Channel Complex Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Response To Calcium Ion Store-operated Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Metal Ion Monoatomic Ion Transport Metal Ion Transport Plasma Membrane Intracellular Calcium Ion Homeostasis Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Regulation Of Calcium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Dendrite Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity G Protein-coupled Glutamate Receptor Binding Transmembrane Transporter Binding Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Muscle Tissue Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Metal Ion Transport Endoplasmic Reticulum Membrane Calcium-mediated Signaling Glutamate Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Transmembrane Transport Intracellular Monoatomic Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Neuron Spine Regulation Of Vasoconstriction Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Caveola Intracellular Signaling Cassette Chemical Homeostasis Signal Transduction ATPase Binding Postsynaptic Density	Inositol 1,4,5 Trisphosphate Binding Acid Secretion Inorganic Ion Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Calcium Ion Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Metal Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Gamma-aminobutyric Acid Transport Monoatomic Cation Transport Cation Channel Complex Microtubule Depolymerization Regulation Of Sequestering Of Calcium Ion Chemical Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Ion Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Intracellular Chemical Homeostasis Protein Depolymerization Microtubule Polymerization Or Depolymerization Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Cellular Homeostasis Carboxylic Acid Transport Organic Acid Transport Homeostatic Process Inorganic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Structural Constituent Of Presynaptic Actin Cytoskeleton Renal Phosphate Ion Absorption Tubulin Binding Monoatomic Ion Transmembrane Transport Regulation Of Sodium Ion Transport Response To Metal Ion Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Organic Anion Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Phenol-containing Compound Metabolic Process Apical Part Of Cell
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