SH3BP4 and TTC1

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		SH3BP4	TTC1
Gene Name		SH3-domain binding protein 4	tetratricopeptide repeat domain 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Coated Pit Clathrin-coated Vesicle Extracellular Vesicular Exosome	Cytoplasm Peroxisomal Membrane
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Ras GTPase Binding Identical Protein Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus	Protein Folding
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Orofacial clefts ( 22419666)
Protein-Protein Interactions		21 interactors: C2orf73 CCT3 CEP78 CIZ1 DNAJA4 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 TCP1 TTC1 TXNL1 YWHAE YWHAG ZBTB37	17 interactors: ACY1 CRY2 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		23677	7265
HPRD ID		09285	11881
Ensembl ID		ENSG00000130147	ENSG00000113312
Uniprot IDs		Q9P0V3	Q99614
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Folding Toxin Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Heat G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Binding Of Sperm To Zona Pellucida Protein Localization Substantia Nigra Development Response To Temperature Stimulus Sperm-egg Recognition Steroid Hormone Receptor Complex Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Positive Regulation Of Mitochondrion Organization 'de Novo' Protein Folding Cell-cell Recognition Cellular Response To Heat Negative Regulation Of Peptidyl-serine Dephosphorylation Cerebellum Structural Organization Regulation Of Heart Rate By Hormone Mitotic Cell Cycle Process Midbrain Development Positive Regulation Of DNA-dependent DNA Replication Initiation Mitotic Cell Cycle Regulation Of Mitochondrion Organization Cell Recognition Single Fertilization Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of DNA-dependent DNA Replication Initiation Cellular Response To Stress Maintenance Of Protein Location In Cell Regulation Of Cell Death	Cellular Response To Stimulus Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Response To Organic Substance Wound Healing Positive Regulation Of Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stress Regulation Of Cell Differentiation Response To Wounding Blood Coagulation Platelet Activation Hemostasis Activation Of MAPKK Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Growth Generation Of Neurons Neurogenesis Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cell Growth Protein Refolding Regulation Of Catalytic Activity Response To Unfolded Protein Post-embryonic Development Locomotion Negative Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Cell Growth Regulation Of Cellular Response To Heat Regulation Of Myeloid Cell Differentiation Negative Regulation Of GTPase Activity Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Skeletal System Development Regulation Of Gene Expression Nervous System Development Activation Of Phospholipase C Activity Regulation Of Signaling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity
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