SH3BP4 and PLEKHA1

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SH3BP4	PLEKHA1
Description		SH3 domain binding protein 4	pleckstrin homology domain containing A1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Small GTPase Binding Identical Protein Binding	Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Endocytosis Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide
Pathways		Amino acids regulate mTORC1	Synthesis of PIPs at the plasma membrane
Drugs			Citric acid
Diseases
GWAS		Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obstetric antiphospholipid syndrome ( 28424481) Orofacial clefts ( 22419666) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Triglyceride levels in HIV infection ( 33109212)	Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Birth weight ( 27680694 31043758) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 20189936 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30718926 30297969 30054458 32499647 28869590 28566273 24509480)
Interacting Genes		23 interacting genes: CCT3 CEP78 CFTR CIMIP6 CIZ1 DNAJA4 EPS15 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 SNCA TCP1 TTC1 TXNL1 YWHAG ZBTB37	8 interacting genes: CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1
Entrez ID		23677	59338
HPRD ID		09285	09686
Ensembl ID		ENSG00000130147	ENSG00000107679
Uniprot IDs		Q9P0V3	B3KQL5 Q5RGS4 Q9HB21
PDB IDs			1EAZ
Enriched GO Terms of Interacting Partners?		Protein Folding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone Cytosol Protein Folding Chaperone Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Heat Shock Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Receptor Recycling Negative Regulation Of Microtubule Polymerization Protein-folding Chaperone Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Receptor Recycling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Refolding Regulation Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Steroid Hormone Receptor Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Phosphoprotein Binding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Binding Of Sperm To Zona Pellucida Sperm-egg Recognition H4/H2A Histone Acetyltransferase Complex ATP Hydrolysis Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Maintenance Of Protein Localization In Organelle Regulation Of Protein Stability Protein Sequestering Activity Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process	Tight Junction Assembly Tight Junction Organization Arginyl-tRNA--protein Transferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Helper T Cell Diapedesis Negative Regulation Of Excitatory Synapse Assembly Protein Arginylation Protein Localization To Vacuole Chordate Pharynx Development Cerebellar Neuron Development Amino Acid Import Lewy Body Core Positive Regulation Of Cell-substrate Adhesion Bicellular Tight Junction Cell-cell Junction Assembly
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