TNFRSF8

Gene Name		tumor necrosis factor receptor superfamily, member 8
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		943
HPRD ID		01074
Ensembl ID		ENSG00000120949
Uniprot IDs		A5D8T4 B9EGD9 D3YTD8 P28908
PDB IDs		1D01
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Signaling NIK/NF-kappaB Signaling Cell Communication Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Regulation Of Gene Expression Protein Ubiquitination Response To Tumor Necrosis Factor Protein Modification By Small Protein Conjugation Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Innate Immune Response Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of MAP Kinase Activity Toll Signaling Pathway Cellular Response To Nitric Oxide CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide
Tagcloud ?		abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine traf2 unexpected