SERPINB9 and GBP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SERPINB9	GBP2
Description		serpin family B member 9	guanylate binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Extracellular Matrix Extracellular Exosome	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Nucleotide Binding GTPase Activity Endopeptidase Inhibitor Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity
	Biological Process	Mast Cell Mediated Immunity Immune Response Negative Regulation Of Endopeptidase Activity Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Process Cellular Response To Estrogen Stimulus	Activation Of Innate Immune Response Immune System Process Immune Response Protein Localization To Nucleus Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Symbiont Entry Into Host Cell Defense Response To Gram-positive Bacterium Protein Maturation Defense Response To Virus Cytolysis In Another Organism Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly
Pathways			Interferon gamma signaling Interferon alpha/beta signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs		Raloxifene
Diseases
GWAS		Left ventricular global circumferential strain ( 33495596) Plateletcrit ( 32888494) Vitiligo ( 27723757)	Serum metabolite levels ( 33031748)
Interacting Genes		28 interacting genes: BRD7 CASP1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 ERG28 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1	22 interacting genes: ANXA7 BID BNIP3L BTBD2 CSNK2B FBXO7 FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG
Entrez ID		5272	2634
HPRD ID		03480	02682
Ensembl ID		ENSG00000170542	ENSG00000162645
Uniprot IDs		A0A024QZT4 P50453	P32456 Q8TCE5
PDB IDs		8ZCR	6VKJ 7E58 7M1S
Enriched GO Terms of Interacting Partners?		Pyroptotic Cell Death NLRP1 Inflammasome Complex Pyroptotic Inflammatory Response Nuclear Matrix Canonical Inflammasome Complex Response To Osmotic Stress Interleukin-18-mediated Signaling Pathway Cellular Response To Type II Interferon CARD Domain Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Cytoplasm Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Intracellular Signal Transduction Protein Heterodimerization Activity Regulation Of Membrane Permeability Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Assembly Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Protein Targeting To Mitochondrion Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of JNK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Microtubule Anchoring At Centrosome Cytoplasmic Translational Initiation Ribonuclease E Activity Spermidine Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Type II Interferon Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Phosphorylation
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