C2 and C5

Number of citations of the paper that reports this interaction (PMID 12878586)
7

Data Source:
HPRD (in vitro)

		C2	C5
Gene Name		complement component 2	complement component 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Chemokine Activity C5a Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Activation Of MAPK Activity In Utero Embryonic Development Leukocyte Migration Involved In Inflammatory Response Cellular Calcium Ion Homeostasis Chemotaxis Response To Stress Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Negative Regulation Of Dopamine Secretion Glucose Homeostasis Innate Immune Response Positive Regulation Of Angiogenesis Positive Regulation Of Chemotaxis Cell Chemotaxis Positive Regulation Of Chemokine Secretion
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Terminal pathway of complement Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling Regulation of Complement cascade Peptide ligand-binding receptors Complement cascade G alpha (i) signalling events Innate Immune System
Drugs			Intravenous Immunoglobulin Eculizumab
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Hepatocellular carcinoma ( 21105107) Prostate cancer ( 23535732)	Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		5 interactors: C3 C4B C5 MASP1 PSMA4	9 interactors: C2 C3 C5AR1 C6 C7 C8B CPB2 CPN1 CREB3L1
Entrez ID		717	727
HPRD ID		08939	00405
Ensembl ID		ENSG00000166278	ENSG00000106804
Uniprot IDs		B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	P01031
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Humoral Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Negative Regulation Of Protein Processing Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation, Alternative Pathway Positive Regulation Of Immune Response Regulation Of Proteolysis Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Negative Regulation Of Catalytic Activity Innate Immune Response Immune System Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Proteolysis Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Regulation Of Endopeptidase Activity Immune Response Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Inflammatory Response Response To Stress Regulation Of Phagocytosis Positive Regulation Of Endocytosis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transport Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Macrophage Chemotaxis	Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Protein Processing Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cytolysis Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Stress Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Apoptotic Cell Clearance Innate Immune Response Regulation Of Apoptotic Cell Clearance Positive Regulation Of Humoral Immune Response Positive Regulation Of Protein Processing Immune System Process Response To Stimulus Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Organ Regeneration Complement Component C5a Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Type IIa Hypersensitivity Protein Metabolic Process Cellular Chemical Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Extracellular Matrix Constituent Secretion Negative Regulation Of Hepatocyte Proliferation Liver Regeneration Bradykinin Catabolic Process Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Cellular Homeostasis
Tagcloud ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Difference) ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Intersection) ?