C2 and PSMA4

Number of citations of the paper that reports this interaction (PMID 8175701)
6

Data Source:
HPRD (in vitro)

		C2	PSMA4
Gene Name		complement component 2	proteasome (prosome, macropain) subunit, alpha type, 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Proteasome Complex Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Plasma Membrane Proteasome Core Complex, Alpha-subunit Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Hepatocellular carcinoma ( 21105107) Prostate cancer ( 23535732)	Lung cancer ( 18385676 18385738 18780872) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		5 interactors: C3 C4B C5 MASP1 PSMA4	12 interactors: C2 CSNK2A1 GOLGA2 IKZF1 PLK1 POMP PSMA1 PSMA2 PSMA3 PSMA5 PSMA6 PSMA7
Entrez ID		717	5685
HPRD ID		08939	10168
Ensembl ID		ENSG00000166278	ENSG00000041357
Uniprot IDs		B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	H0YN18 P25789 Q7Z474
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Humoral Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Negative Regulation Of Protein Processing Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation, Alternative Pathway Positive Regulation Of Immune Response Regulation Of Proteolysis Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Negative Regulation Of Catalytic Activity Innate Immune Response Immune System Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Proteolysis Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Regulation Of Endopeptidase Activity Immune Response Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Inflammatory Response Response To Stress Regulation Of Phagocytosis Positive Regulation Of Endocytosis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transport Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Macrophage Chemotaxis	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Negative Regulation Of Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process
Tagcloud ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	aminotransferase brilliant caffeic calibrated cape coomassie deaminase densitometer gels glucosamine glyceraldehyde gnpda1 gpx guanine isomerase match myosin pdquest phenethyl phosphoserine psat1 psma1 sw480 synthetase tim triosephosphate tryptophanyl xviiib
Tagcloud (Difference) ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	aminotransferase brilliant caffeic calibrated cape coomassie deaminase densitometer gels glucosamine glyceraldehyde gnpda1 gpx guanine isomerase match myosin pdquest phenethyl phosphoserine psat1 psma1 sw480 synthetase tim triosephosphate tryptophanyl xviiib
Tagcloud (Intersection) ?