C5 and C6

Number of citations of the paper that reports this interaction (PubMedID 1387399)
0

Data Source:
HPRD (in vitro)

		C5	C6
Description		complement C5	complement C6
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity	Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	In Utero Embryonic Development Immune System Process Immune Response Complement Activation Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)	Refractive error ( 32231278) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT	4 interacting genes: C5 F2 OGA SART3
Entrez ID		727	729
HPRD ID		00405	01956
Ensembl ID		ENSG00000106804	ENSG00000039537
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	P13671
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ	3T5O 4A5W 4E0S 6H03 6H04 7NYC 7NYD 7Q6C 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	Receptor Ligand Activity Killing Of Cells Of Another Organism U4atac/U6atac SnRNP U6atac SnRNA Binding U6atac SnRNP [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity Cell Killing U4/U6 SnRNP Hexosaminidase Activity Thrombospondin Receptor Activity ASAP Complex Catalytic Activity, Acting On A Protein Humoral Immune Response Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Transcription Elongation-coupled Chromatin Remodeling U4 SnRNA Binding Hyalurononglucosaminidase Activity Complement Activation, Lectin Pathway Transmembrane Transporter Complex Signaling Receptor Binding Negative Regulation Of Macrophage Migration Complement Activation, GZMK Pathway Immune Effector Process Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Astrocyte Differentiation Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis U6 SnRNA Binding Complement Activation, Alternative Pathway N-acetylglucosamine Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Spliceosomal Tri-snRNP Complex Assembly Fibrinolysis Ubiquitin-specific Protease Binding Protein Deglycosylation Negative Regulation Of Leukocyte Chemotaxis Neutrophil Mediated Immunity Positive Regulation Of Collagen Biosynthetic Process Inflammatory Response Negative Regulation Of Glial Cell Differentiation Hematopoietic Stem Cell Proliferation Positive Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Chemotaxis
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