C5 and KEL

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		C5	KEL
Name		complement C5	Kell metallo-endopeptidase (Kell blood group)
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	Proteolysis Intracellular Calcium Ion Homeostasis Regulation Of Cell Size Intracellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Peptide ligand-binding receptors
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab	Phosphoramidon
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	None
GWAS		Blood protein levels ( 30072576 ) Coronary artery disease ( 29212778 ) Hip circumference adjusted for BMI ( 25673412 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 19503088 24390342 30891314 )	Alcoholic chronic pancreatitis ( 28754779 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 )
Novel Interactors		9 novel interactors: LIMK1 LRSAM1 NEK6 PIGP PRDM16 PRKCZ SARDH SLC10A2 SPTAN1	2 novel interactors: AGPS EMC1
Interacting Genes		22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT	12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK
Entrez ID		727	3792
HPRD ID		00405	00194
Ensembl ID		ENSG00000106804	ENSG00000197993
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	A0A077QP03 P23276
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ	Not available
GO Terms Enriched among Interactors		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	Endothelin B Receptor Binding Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Hormone Activity Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Heart Contraction Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure Axon Extension Regulation Of Blood Pressure Positive Regulation Of Muscle Contraction Intracellular Magnesium Ion Homeostasis Neutrophil Chemotaxis Smooth Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Cell Chemotaxis Regulation Of Chemotaxis Regulation Of Vasoconstriction Neutrophil Migration Positive Regulation Of Prostaglandin Biosynthetic Process Calcium Ion Homeostasis Regulation Of Leukocyte Migration Leukocyte Migration Granulocyte Chemotaxis Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Extension Endothelin Receptor Signaling Pathway Regulation Of Prostaglandin Biosynthetic Process Magnesium Ion Homeostasis Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Fatty Acid Metabolic Process Regulation Of Cell Migration Regulation Of Heart Rate Regulation Of Cell Motility Regulation Of Locomotion Chemotaxis Developmental Cell Growth Response To Tumor Necrosis Factor Regulation Of Ketone Metabolic Process Myeloid Leukocyte Migration Locomotion