C5 and C7

Number of citations of the paper that reports this interaction (PubMedID 1387399)
0

Data Source:
HPRD (in vitro)

		C5	C7
Description		complement C5	complement C7
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)	Clozapine-induced cytotoxicity ( 25656473) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT	4 interacting genes: C5 CFTR CLU PLG
Entrez ID		727	730
HPRD ID		00405	01957
Ensembl ID		ENSG00000106804	ENSG00000112936
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	P10643 Q05CI3
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ	2WCY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	Protein-folding Chaperone Binding Regulation Of Multicellular Organismal Process Signaling Receptor Binding Complement Activation Complement Activation, Classical Pathway Cholesterol Transport Platelet Alpha Granule Lumen Sterol Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Receptor Ligand Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Anion Channel Activity Cell Surface Positive Regulation Of Neurofibrillary Tangle Assembly Blood Microparticle Protein-containing Complex Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Enamel Mineralization Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis POZ Domain Binding Transepithelial Water Transport Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Leukocyte Migration Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Protein Import Regulation Of Neurofibrillary Tangle Assembly Humoral Immune Response Bicarbonate Transmembrane Transporter Activity
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