C2 and MASP1

Number of citations of the paper that reports this interaction (PMID 10946292)
29

Data Source:
HPRD (in vitro)

		C2	MASP1
Gene Name		complement component 2	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation Innate Immune Response Negative Regulation Of Complement Activation
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Hepatocellular carcinoma ( 21105107) Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: C3 C4B C5 MASP1 PSMA4	15 interactors: C2 C3 FCN2 GADD45A GSK3B H2AFX MAPK6 MAPK8IP2 MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1L
Entrez ID		717	5648
HPRD ID		08939	02749
Ensembl ID		ENSG00000166278	ENSG00000127241
Uniprot IDs		B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	P48740
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Humoral Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Negative Regulation Of Protein Processing Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation, Alternative Pathway Positive Regulation Of Immune Response Regulation Of Proteolysis Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Negative Regulation Of Catalytic Activity Innate Immune Response Immune System Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Proteolysis Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Regulation Of Endopeptidase Activity Immune Response Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Inflammatory Response Response To Stress Regulation Of Phagocytosis Positive Regulation Of Endocytosis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transport Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Macrophage Chemotaxis	Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune System Process Regulation Of Immune Response Defense Response Response To Stress Positive Regulation Of Immune System Process Regulation Of Complement Activation Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Response To External Stimulus Negative Regulation Of Cellular Protein Metabolic Process Immune Response Regulation Of Phagocytosis Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune System Process Regulation Of Protein Metabolic Process Leukocyte Mediated Immunity Opsonization Regulation Of Apoptotic Cell Clearance Adaptive Immune Response Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Signal Complex Assembly Positive Regulation Of Endocytosis Response To Stimulus Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Part Morphogenesis Regulation Of Phosphorus Metabolic Process Cellular Response To Stress
Tagcloud ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	accessibility adding attribute biocompatibility biodegradability bioengineered biomaterial clavipes combines desired doxorubicin enabling engineering functionalization functionalized h2 hybrids impede internalized loaded ms1 reasonable silk silks sphere spheres spider tag unless
Tagcloud (Difference) ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	accessibility adding attribute biocompatibility biodegradability bioengineered biomaterial clavipes combines desired doxorubicin enabling engineering functionalization functionalized h2 hybrids impede internalized loaded ms1 reasonable silk silks sphere spheres spider tag unless
Tagcloud (Intersection) ?