C2 and STOM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C2	STOM
Description		complement C2	stomatin
Image
GO Annotations	Cellular Component	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Cell Surface Extracellular Exosome Symbiont Cell Surface	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Opsonization Response To Bacterium Killing Of Cells Of Another Organism Response To Lipopolysaccharide Innate Immune Response Protein Maturation Response To Thyroid Hormone Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade	Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle
Drugs
Diseases		Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS		A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age at first sexual intercourse ( 34211149) Age-related macular degeneration ( 20385826 23455636 20385819 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Circulating myeloperoxidase levels (serum) ( 23620142) Clostridioides difficle infection ( 33841421) Coffee consumption ( 31046077) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Hepatocellular carcinoma ( 21105107) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35H1 STOM	81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6
Entrez ID		717	2040
HPRD ID		08939	00585
Ensembl ID		ENSG00000166278	ENSG00000148175
Uniprot IDs		A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	F8VSL7 P27105
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB 8ACF 8ACI	7WH3
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Complement Activation Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Opsonization Symbiont Cell Surface Humoral Immune Response Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Immune Effector Process Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Activation Of Membrane Attack Complex Positive Regulation Of Inflammatory Response To Antigenic Stimulus Extracellular Space Positive Regulation Of Immune System Process Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Innate Immune Response Receptor Ligand Activity Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Mononuclear Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Production Defense Response To Symbiont Defense Response To Other Organism Antigen Binding Positive Regulation Of Transport Cell Killing Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Lipid Storage Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Chemokine Activity Regulation Of Acute Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Leukocyte Migration Extracellular Exosome Regulation Of Immune Response Leukocyte Migration	Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane
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