C2

Name	complement C2
Structure
Novel Interactors	1 novel interactors: TNF
Interactors	14 interactors: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35H1 STOM
GO Annotations	Cellular Component	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Cell Surface Extracellular Exosome Symbiont Cell Surface
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Opsonization Response To Bacterium Killing Of Cells Of Another Organism Response To Lipopolysaccharide Innate Immune Response Protein Maturation Response To Thyroid Hormone Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Diseases	Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS	A body shape index ( 34021172 ) Advanced age-related macular degeneration ( 26691988 ) Age at first sexual intercourse ( 34211149 ) Age-related macular degeneration ( 20385826 23455636 20385819 21665990 ) Age-related macular degeneration (choroidal neovascularisation) ( 22705344 ) Age-related macular degeneration (geographic atrophy) ( 22705344 ) Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Circulating myeloperoxidase levels (serum) ( 23620142 ) Clostridioides difficle infection ( 33841421 ) Coffee consumption ( 31046077 ) Coronary artery disease ( 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Disease progression in age-related macular degeneration ( 29346644 ) Early age-related macular degeneration ( 32843070 ) Endometriosis ( 28881265 ) Estimated glomerular filtration rate ( 31451708 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hepatocellular carcinoma ( 21105107 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Mosquito bite size ( 28199695 ) Platelet aggregation ( 29185836 ) Prostate cancer ( 23535732 ) Sulfasalazine-induced agranulocytosis ( 28762467 ) Systemic lupus erythematosus ( 24871463 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Youthful appearance (self-reported) ( 32339537 )
Entrez ID	717
HPRD ID	08939
Ensembl ID	ENSG00000166278
Uniprot IDs	A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6
PDB IDs	2I6Q 2I6S 2ODP 2ODQ 3ERB 8ACF 8ACI
GO Terms Enriched among Interactors ?	Complement Activation, Lectin Pathway Complement Activation Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Opsonization Symbiont Cell Surface Humoral Immune Response Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Immune Effector Process Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Activation Of Membrane Attack Complex Positive Regulation Of Inflammatory Response To Antigenic Stimulus Extracellular Space Positive Regulation Of Immune System Process Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Innate Immune Response Receptor Ligand Activity Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Mononuclear Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Production Defense Response To Symbiont Defense Response To Other Organism Antigen Binding Positive Regulation Of Transport Cell Killing Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Lipid Storage Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Chemokine Activity Regulation Of Acute Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Leukocyte Migration Extracellular Exosome Regulation Of Immune Response Leukocyte Migration