C5 and C8B

Number of citations of the paper that reports this interaction (PubMedID 3624872)
0

Data Source:
HPRD (in vitro)

		C5	C8B
Description		complement C5	complement C8 beta chain
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex Extracellular Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity	Protein-containing Complex Binding
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab	Zinc Copper Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)	Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT	3 interacting genes: C5 C8A CLU
Entrez ID		727	732
HPRD ID		00405	00410
Ensembl ID		ENSG00000106804	ENSG00000021852
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	A0A8Q3WL56 B7Z550 B7Z555 P07358
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ	3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	Complement Activation, Classical Pathway Complement Activation Other Organism Cell Membrane Membrane Attack Complex Transmembrane Transporter Complex Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Humoral Immune Response Immune Effector Process Activation Of Immune Response Innate Immune Response Positive Regulation Of Immune Response Defense Response To Other Organism Defense Response To Symbiont Regulation Of Immune Response Receptor Ligand Activity Killing Of Cells Of Another Organism Blood Microparticle Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Positive Regulation Of Immune System Process Response To Other Organism Immune Response Cell Killing Positive Regulation Of Neurofibrillary Tangle Assembly Response To External Biotic Stimulus Defense Response Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Extracellular Space Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Regulation Of Immune System Process Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Macrophage Chemotaxis Complement Binding Protein Import Protein-containing Complex Binding Immune System Process Spherical High-density Lipoprotein Particle Signaling Receptor Binding Microglial Cell Proliferation Extracellular Exosome Protein Carrier Chaperone Extracellular Region
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