C5 and C5AR1

Number of citations of the paper that reports this interaction (PubMedID 9553099)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		C5	C5AR1
Description		complement C5	complement C5a receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Plasma Membrane Membrane Basolateral Plasma Membrane Secretory Granule Membrane Cytoplasmic Vesicle Apical Part Of Cell
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Signaling Neutrophil Chemotaxis Response To Peptidoglycan Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab	Avacopan
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)	Chronic periodontitis ( 25008200)
Interacting Genes		22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT	7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS
Entrez ID		727	728
HPRD ID		00405	00224
Ensembl ID		ENSG00000106804	ENSG00000197405
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	P21730
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ	2K3U 5O9H 6C1Q 6C1R 7Y64 7Y65 7Y66 7Y67 8GO8 8GOO 8HK5 8I0N 8I0Z 8IA2 8JZP 8JZZ
Enriched GO Terms of Interacting Partners?		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	G Protein-coupled Receptor Binding Angiotensin Receptor Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway Chemotaxis Locomotion Regulation Of Immune Response G Protein-coupled Receptor Internalization Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Receptor Internalization Cell Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cytokine Production Postsynaptic Signal Transduction Negative Regulation Of Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Leukocyte Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Locomotion Endocytic Vesicle Membrane Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Receptor Internalization Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Motility Regulation Of T Cell Antigen Processing And Presentation Regulation Of Locomotion Regulation Of Interleukin-8 Production Negative Regulation Of Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Innate Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Vesicle-mediated Transport
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