C2 and C4B

Number of citations of the paper that reports this interaction (PMID 11341920)
4

Data Source:
BioGRID (pull down)

		C2	C4B
Gene Name		complement component 2	complement component 4B (Chido blood group)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Other Organism Cell Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Complement Binding Endopeptidase Inhibitor Activity Carbohydrate Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Detection Of Molecule Of Bacterial Origin Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Hepatocellular carcinoma ( 21105107) Prostate cancer ( 23535732)	Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: C3 C4B C5 MASP1 PSMA4	1 interactors: C2
Entrez ID		717	721
HPRD ID		08939
Ensembl ID		ENSG00000166278	ENSG00000224389
Uniprot IDs		B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	P0C0L4 P0C0L5
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB	1HZF 4FXG 4FXK
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Humoral Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Negative Regulation Of Protein Processing Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation, Alternative Pathway Positive Regulation Of Immune Response Regulation Of Proteolysis Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Negative Regulation Of Catalytic Activity Innate Immune Response Immune System Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Proteolysis Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Regulation Of Endopeptidase Activity Immune Response Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Inflammatory Response Response To Stress Regulation Of Phagocytosis Positive Regulation Of Endocytosis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transport Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Macrophage Chemotaxis	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Regulation Of Complement Activation Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Regulation Of Phagocytosis Regulation Of Acute Inflammatory Response Positive Regulation Of Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Endocytosis Response To Nutrient Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Regulation Of Vesicle-mediated Transport Regulation Of Protein Processing Response To Nutrient Levels Response To Extracellular Stimulus Positive Regulation Of Immune Response
Tagcloud ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	alleles antitopoisomerase backgrounds c4a c4aq0 c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Difference) ?		3gal analogue anhydro attacks axial catalyzes charged decora enzymatic generalized glycerol inactive instead intramolecular leech linkage macrobdella neu5ac neu5acalpha2 o7 propenyl pyranose sialidase sialoglycoconjugates sialosyl strict superfamily supports trans	alleles antitopoisomerase backgrounds c4a c4aq0 c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Intersection) ?