S100A4 and METAP2

Number of citations of the paper that reports this interaction (PubMedID 11994292)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		S100A4	METAP2
Description		S100 calcium binding protein A4	methionyl aminopeptidase 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Chemoattractant Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding	RNA Binding Aminopeptidase Activity Initiator Methionyl Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Epithelial To Mesenchymal Transition Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Chemotaxis	Regulation Of Translational Initiation Proteolysis Protein Processing
Pathways			Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Trifluoperazine Copper	Methionine Nitroxoline 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamide tert-butanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin PPI-2458 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID TNP-470
Diseases
GWAS		Pulse pressure ( 30578418)	Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels ( 23823483) Reticulocyte count ( 32888494)
Interacting Genes		29 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 IFNB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119	16 interacting genes: APP CALM1 CDC42 CEBPA DSCAM EIF2AK2 EIF2S3 FBXL17 HMGA1 MAPK1 MAPK3 OGT PJA1 RAC1 S100A4 YWHAE
Entrez ID		6275	10988
HPRD ID		15914	03522
Ensembl ID		ENSG00000196154	ENSG00000111142
Uniprot IDs		P26447	A0A140VJE3 F8VQZ7 P50579
PDB IDs		1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58 7PSP 7PSQ	1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ 7A12 7A13 7A14 7A15 7A16 8ONY 8OXG 9FPZ
Enriched GO Terms of Interacting Partners?		Cytoplasm Identical Protein Binding Cleavage Furrow Actin Filament Binding Myosin II Complex Myosin Filament Spindle Sperm Annulus Stress Fiber Microfilament Motor Activity Cytoskeleton-dependent Cytokinesis Supramolecular Fiber Cytosol S100 Protein Binding Cell Division Site Septin Ring Septin Complex Cytoskeletal Motor Activity Myosin Complex Regulation Of Developmental Process Actin Filament-based Movement Regulation Of Cell Shape Cellular Response To Actinomycin D Myosin II Filament Calcium-dependent Protein Binding Cadherin Binding Cytoskeleton Supramolecular Fiber Organization Midbody Response To Actinomycin D Muscle Thin Filament Tropomyosin Muscle Contraction Regulation Of Protein Kinase C Signaling Cellular Response To UV-C Actin Binding ADP Binding Actin-mediated Cell Contraction Negative Regulation Of Protein Catabolic Process Regulation Of Cell Morphogenesis Regulation Of Plasma Membrane Repair Muscle System Process Nucleotide Binding Cell Adhesion Cellular Developmental Process System Process Actin Cytoskeleton Regulation Of Protein Localization Sarcomere Positive Regulation Of Gene Expression Regulation Of Protein Processing	Intracellular Signal Transduction Positive Regulation Of Chemotaxis Intracellular Signaling Cassette Response To Peptide Response To Cytokine Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Focal Adhesion Endocytosis Regulation Of Intracellular Signal Transduction Interleukin-34-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of Golgi Inheritance Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Calcium Ion Export Across Plasma Membrane Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Signal Transduction Positive Regulation Of Leukocyte Migration Substantia Nigra Development Positive Regulation Of Locomotion Regulation Of Calcium Ion Export Across Plasma Membrane Import Into Cell Regulation Of Granulocyte Chemotaxis Positive Regulation Of Inflammatory Response G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Glial Cell Development Neural Nucleus Development Cellular Response To Amino Acid Starvation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Amino Acid Starvation Cellular Response To Cytokine Stimulus Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Thioesterase Binding Bergmann Glial Cell Differentiation Vesicle-mediated Transport
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