S100A4 and IFNB1

Number of citations of the paper that reports this interaction (PubMedID 33322098)
72

Data Source:
BioGRID (pull down)

		S100A4	IFNB1
Description		S100 calcium binding protein A4	interferon beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Chemoattractant Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding Chloramphenicol O-acetyltransferase Activity
	Biological Process	Epithelial To Mesenchymal Transition Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Chemotaxis	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of Immune System Process Regulation Of Transcription By RNA Polymerase II Response To Stress Defense Response Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Innate Immune Response Leukocyte Activation Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Type I Interferon-mediated Signaling Pathway Neuron Cellular Homeostasis Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of Lewy Body Formation Antiviral Innate Immune Response Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Trifluoperazine Copper	Beta-D-Glucose
Diseases
GWAS		Pulse pressure ( 30578418)	Axial length ( 24144296)
Interacting Genes		29 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 IFNB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119	8 interacting genes: IFNAR1 IFNAR2 PEX19 S100A1 S100A4 S100A6 S100B S100P
Entrez ID		6275	3456
HPRD ID		15914	00972
Ensembl ID		ENSG00000196154	ENSG00000171855
Uniprot IDs		P26447	P01574
PDB IDs		1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58 7PSP 7PSQ	1AU1
Enriched GO Terms of Interacting Partners?		Cytoplasm Identical Protein Binding Cleavage Furrow Actin Filament Binding Myosin II Complex Myosin Filament Spindle Sperm Annulus Stress Fiber Microfilament Motor Activity Cytoskeleton-dependent Cytokinesis Supramolecular Fiber Cytosol S100 Protein Binding Cell Division Site Septin Ring Septin Complex Cytoskeletal Motor Activity Myosin Complex Regulation Of Developmental Process Actin Filament-based Movement Regulation Of Cell Shape Cellular Response To Actinomycin D Myosin II Filament Calcium-dependent Protein Binding Cadherin Binding Cytoskeleton Supramolecular Fiber Organization Midbody Response To Actinomycin D Muscle Thin Filament Tropomyosin Muscle Contraction Regulation Of Protein Kinase C Signaling Cellular Response To UV-C Actin Binding ADP Binding Actin-mediated Cell Contraction Negative Regulation Of Protein Catabolic Process Regulation Of Cell Morphogenesis Regulation Of Plasma Membrane Repair Muscle System Process Nucleotide Binding Cell Adhesion Cellular Developmental Process System Process Actin Cytoskeleton Regulation Of Protein Localization Sarcomere Positive Regulation Of Gene Expression Regulation Of Protein Processing	Calcium-dependent Protein Binding S100 Protein Binding Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Calcium Ion Binding RAGE Receptor Binding Response To Interferon-alpha Transition Metal Ion Binding Cellular Response To Interferon-beta Extracellular Region Response To Interferon-beta Cytokine Binding Protein Homodimerization Activity Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Identical Protein Binding Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT ATPase Binding Interferon Receptor Activity Positive Regulation Of Protein Localization To Nucleus Peroxisome Membrane Targeting Sequence Binding Ruffle Peroxisome Membrane Biogenesis Regulation Of Protein Localization To Nucleus Axonogenesis Protein Import Into Peroxisome Membrane Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Membrane Biogenesis Perinuclear Region Of Cytoplasm Negative Regulation Of Skeletal Muscle Cell Differentiation Receptor Complex Cellular Response To Interferon-alpha Protein Targeting To Peroxisome Protein Carrier Chaperone Positive Regulation Of Canonical NF-kappaB Signal Transduction Peroxisome Fission Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Respiration Tropomyosin Binding Neuron Projection Morphogenesis A Band Cell Projection Morphogenesis
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